Medicament for therapeutic treatment and/or improvement of sepsis
AssigneeAsahi Kasei Pharma Corporation
InventorsKazuhisa Tsuruta, Yoshikazu Aoki, Yutaka Osawa, Inder Kaul
Life of this patent
Estimating the term…
Abstract
A medicament for therapeutic treatment and/or improvement of sepsis in a patient with severe sepsis accompanied with one or more organ dysfunctions, wherein a value of International Normalized Ratio (INR) of a plasma specimen obtained from said patient is more than 1.4, which comprises thrombomodulin as an active ingredient.
Claims39
A method for therapeutic treatment of sepsis, which comprises the step of:
- administering thrombomodulin to a patient with severe sepsis, accompanied with one or more organ dysfunctions selected from the group consisting of liver dysfunction, kidney dysfunction, respiratory organ dysfunction and circulatory organ dysfunction, wherein a value of International Normalized Ratio (INR) of a plasma specimen obtained from said patient is more than 1.4.
A method for therapeutic treatment of sepsis, which comprises the step of:
- intravenously administering thrombomodulin to a patient with severe sepsis, accompanied with one or more organ dysfunctions selected from the group consisting of liver dysfunction, kidney dysfunction, respiratory organ dysfunction and circulatory organ dysfunction, wherein a value of International Normalized Ratio (INR) of a plasma specimen obtained from said patient is more than 1.4, wherein said thrombomodulin is administered at a dose of 0.04-0.08 mg/kg/day.
A method for therapeutic treatment of sepsis, which comprises the step of:
- intravenously administering thrombomodulin to a patient with severe sepsis, accompanied with one or more organ dysfunctions selected from the group consisting of liver dysfunction, kidney dysfunction, respiratory organ dysfunction and circulatory organ dysfunction, wherein a value of International Normalized Ratio (INR) of a plasma specimen obtained from said patient is more than 1.4, wherein said thrombomodulin is administered at a daily dose of 0.05 mg/kg or more.
A method for decreasing the mortality of patients with sepsis, which comprises the step of:
- administering thrombomodulin to patients with severe sepsis, accompanied with one or more organ dysfunctions selected from the group consisting of liver dysfunction, kidney dysfunction, respiratory organ dysfunction and circulatory organ dysfunction, wherein a value of International Normalized Ratio (INR) of a plasma specimen obtained from said patients is more than 1.4.
Dependencies are inferred from the claim text.