# US 8,772,230 B2 · Niacin and/or trigonelline as a muscle stimulant

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- Number: US 8,772,230 B2
- Document ID: US8772230B2
- Status: Granted
- Kind: B2
- Application number: 13/321,971
- Filed: 2010-06-10
- Published: 2012-07-26
- Granted: 2014-07-08
- Earliest claimed: 2009-06-11
- Assignees: Dsm IP Assets B.V.
- Applicants: Angelika Friedel; Karin Kuratli; Christof Wehrli; Karin Wertz; Swen Wolfram; Ying Wang-Schmidt
- Inventors: Angelika Friedel; Karin Kuratli; Christof Wehrli; Karin Wertz; Swen Wolfram; Ying Wang-Schmidt
- Web page: https://patentgrep.com/patent/US8772230B2

## CPC

- A61K 31/455: Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A23L 33/15: Vitamins
- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A61K 31/46: 8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A61K 36/00: Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines {(antigens from pollen A61K39/36)}
- A61K 36/742: {Coffea, e.g. coffee}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 3/02: Nutrients, e.g. vitamins, minerals
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

This invention relates to the use of niacin and/or trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.

## Claims

### Claim 1

A method of decreasing the amount of muscle mass loss comprising administering trigonelline and/or a salt or ester thereof to a subject experiencing muscle atrophy.

### Claim 2 (depends on 1)

The method of claim 1 wherein the subject is a human.

### Claim 3 (depends on 1)

The method of claim 1 wherein the subject is a non-human animal.

### Claim 4 (depends on 1)

The method of claim 1 wherein the trigonelline and/or salt or ester thereof is administered in combination with a protein and/or vitamin(s).

### Claim 5 (depends on 1)

The method of claim 1 wherein the administration results in improved mobility.

### Claim 6 (depends on 1)

The method of claim 1 wherein the muscle atrophy is sarcopenia.

### Claim 7 (depends on 1)

The method of claim 1 wherein the atrophy is due to lessened muscle activity.

### Claim 8 (depends on 6)

The method of claim 6, wherein the sarcopenia occurs during an illness or surgery.

### Claim 9 (depends on 6)

The method of claim 6 wherein the sarcopenia occurs during bed rest.