# US 8,771,976 B2 · Method of cancer diagnosis using the analysis of isotopes

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- Number: US 8,771,976 B2
- Document ID: US8771976B2
- Status: Granted
- Kind: B2
- Application number: 12/674,425
- Filed: 2007-10-17
- Published: 2013-07-11
- Granted: 2014-07-08
- Earliest claimed: 2007-08-27
- Applicants: Won Cheol Choi
- Inventors: Won Cheol Choi
- Web page: https://patentgrep.com/patent/US8771976B2

## CPC

- A61P 39/06: Free radical scavengers or antioxidants
- G01N 33/5758: {involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites}
- C12Q 1/04: Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor {(C12Q1/6897 takes precedence)}
- G01N 33/49: Blood {(chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80)}
- G01N 33/57505: of the blood, e.g. leukaemia
- G01N 33/57515: of the breast
- G01N 33/5752: of the lungs
- G01N 33/57525: of the liver or pancreas
- G01N 33/5753: of the stomach or small intestine
- G01N 33/84: involving inorganic compounds or pH
- H01J 49/0027: {Methods for using particle spectrometers}
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- H01J: ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS (spark-gaps H01T; electric arc lamps H05B31/00; particle accelerators H05H)

## Abstract

Disclosed is a method of diagnosing cancer on the basis of the quantitative analysis of blood or tissue isotopes. The method can accurately diagnose cancer even when it is too small for current conventional technology to diagnose.

## Claims

### Claim 1

A method of diagnosing cancer in a patient, comprising
(a) measuring the level of isotope 36S in a blood sample or a tissue sample of the patient using a double-focus type mass spectrophotometer;
(b) measuring the level of at least one of the calcium isotopes 42Ca, 43Ca, 44Ca, 46Ca and 48Ca in a blood sample or a tissue sample of the patient using a double-focus type mass spectrophotometer;
(c) diagnosing cancer in the patient if (i) 36S is not detected
and (ii) the level of the at least one calcium isotope is greater than the level of a normal standard for the at least one calcium isotope.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the method further comprises measuring the level of 33S in a blood sample or a tissue sample of the patient and diagnosing cancer in the patient if more than 1.3 times increased level of 33S is detected in the blood sample or tissue sample of the patient compared to a normal standard for 33S.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the method further comprises measuring the level of 34S in a blood sample or a tissue sample of the patient and diagnosing cancer in the patient if more than 3.4 times increased level of 34S is detected in the blood sample or tissue sample of the patient compared to a normal standard for 34S.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the level of the at least once calcium isotope is greater than 2.8 times the normal standard for the at least one calcium isotope.