# US 8,771,941 B2 · Methods of assessing the risk of reproductive failure by measuring telomere length

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- Number: US 8,771,941 B2
- Document ID: US8771941B2
- Status: Granted
- Kind: B2
- Application number: 12/482,176
- Filed: 2009-06-10
- Published: 2009-12-31
- Granted: 2014-07-08
- Earliest claimed: 2002-10-16
- Assignees: David L. Keefe
- Applicants: David L. Keefe
- Inventors: David L. Keefe
- Web page: https://patentgrep.com/patent/US8771941B2

## CPC

- C12Q 1/6883: for diseases caused by alterations of genetic material
- A61B 17/435: for embryo {or ova} transplantation
- C12Q 1/68: involving nucleic acids
- C12Q 1/6827: for detection of mutation or polymorphism
- C12Q 1/6841: In situ hybridisation
- C12Q 1/6888: for detection or identification of organisms
- C12Q 2600/156: Polymorphic or mutational markers
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

The invention features a method of identifying oocytes with a risk of reproductive failure and/or aneuploidy based on a telomere length assay.

## Claims

### Claim 1

A method of in vitro fertilization comprising:
obtaining at least one chromosome from the polar body of a fertilized human oocyte;
measuring telomere length of the at least one chromosome;
selecting a fertilized human oocyte having a polar body for with the measured telomere length is 7.5 kb ±1.17 kb; and
after a period of incubation, implanting the embryo resulting from the selected fertilized human oocyte in a human subject.

### Claim 2

A method for optimizing the viability of a human embryo comprising:
obtaining at least one chromosome from the polar body of a fertilized human oocyte;
measuring telomere length of the at least one chromosome;
selecting a fertilized human oocyte having a polar body for which the measured telomere length is 7.5 kb ±1.17 kb; and
after a period of incubation, implanting the embryo resulting from the selected fertilized human oocyte in a human subject.