# US 8,771,764 B2 · Composition and method for improving vascular health > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,771,764 B2 - Document ID: US8771764B2 - Status: Granted - Kind: B2 - Application number: 13/376,628 - Filed: 2010-06-08 - Published: 2012-06-07 - Granted: 2014-07-08 - Earliest claimed: 2009-06-09 - Assignees: Malaysian Palm Oil Board; Commonwealth Scientific and Industrial Research Organisation (CSIRO) - Applicants: Mahinda Abeywardena; Ravigadevi Sambanthamurthi; Yew Ai Tan; Kalyana Sundram P. Manickam; Mohd Basri Wahid - Inventors: Mahinda Abeywardena; Ravigadevi Sambanthamurthi; Yew Ai Tan; Kalyana Sundram P. Manickam; Mohd Basri Wahid - Web page: https://patentgrep.com/patent/US8771764B2 ## CPC - A61K 36/889: Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto - A23L 33/105: Plant extracts, their artificial duplicates or their derivatives - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61P 9/00: Drugs for disorders of the cardiovascular system - A61P 9/06: Antiarrhythmics - A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis - A61P 9/12: Antihypertensives - A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION ## Abstract The present invention relates to a composition for the use in improving vascular health, including treating and preventing vascular diseases and diseases related thereto, using a botanical extract of oil palm vegetation liquor from the palm oil milling process. ## Claims ### Claim 1 A method for the treatment of a cardiovascular disease in a subject in need thereof, said method comprising administering to said subject an effective amount of a water soluble extract obtained from vegetation liquor of a palm oil milling process, wherein said extract does not contain components having a molecular weight above 41,000 Daltons. ### Claim 2 (depends on 1) The method of claim 1, wherein the soluble extract from vegetation liquor is from an oil palm fruit bunch which includes the fruit, spikelet and stalk. ### Claim 3 (depends on 1) The method of claim 1, wherein the soluble extract from vegetation liquor is from an oil palm frond. ### Claim 4 (depends on 1) The method of claim 1, wherein the cardio vascular disease is selected from the group consisting of hypertension and associated maladies, atherosclerosis and cardiac arrhythmias. ### Claim 5 (depends on 1) The method of claim 1, wherein said method results in at least one of the following: promoting vascular health, improving vascular integrity thus limiting adherence of cells and build up of fatty plaques, inducing vasodilatation, reducing overall oxidative burden, limiting and thus inhibiting the oxidation of LDL cholesterol, inhibiting atheroma formation, lowering blood pressure, reducing cardiac and vascular hypertrophy, improving renal function, providing cardio protective effect, reducing the risk of atherogenesis and maintaining heart rhythm at normal rate in event that the blood flow is impaired or disrupted. ### Claim 6 (depends on 1) The method of claim 1 wherein said method increases or promotes availability of NO and vaso relaxation. ### Claim 7 (depends on 1) The method of claim 1 wherein the composition is provided in dose dependent manner. ### Claim 8 (depends on 1) The method of claim 1 wherein the composition is provided in solid dosage form. ### Claim 9 (depends on 1) The method of claim 1 wherein the composition is provided in liquid dosage form. ### Claim 10 (depends on 1) The method of claim 1 wherein the composition is provided in solution form. ### Claim 11 (depends on 1) The method of claim 1 wherein the composition is provided in a pharmaceutically effective form. ### Claim 12 (depends on 1) The method of claim 1 wherein the composition is provided in nutraceutical form. ### Claim 13 (depends on 1) The method of claim 1 wherein the composition is in nutritional supplementary form. ### Claim 14 (depends on 1) The method of claim 1 wherein the composition is in suppository form. ### Claim 15 (depends on 1) The method of claim 1 wherein the composition is provided in a form suitable for oral administration. ### Claim 16 (depends on 1) The method of claim 1 wherein the composition is provided in a form suitable for intravenous administration.