# US 8,771,759 B2 · Topical anti-inflammatory combination

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- Number: US 8,771,759 B2
- Document ID: US8771759B2
- Status: Granted
- Kind: B2
- Application number: 13/055,081
- Filed: 2009-07-15
- Published: 2011-06-23
- Granted: 2014-07-08
- Earliest claimed: 2008-07-22
- Assignees: Izun Pharmaceuticals Corp.
- Applicants: William Zev Levine; Aron Jay Saffer; Gabriel Nussbaum
- Inventors: William Zev Levine; Aron Jay Saffer; Gabriel Nussbaum
- Web page: https://patentgrep.com/patent/US8771759B2

## CPC

- A61K 36/185: Magnoliopsida (dicotyledons)
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 31/14: Quaternary ammonium compounds, e.g. edrophonium, choline (betaines A61K31/205)
- A61K 31/4425: Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
- A61K 36/23: Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K 36/28: Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K 36/35: Caprifoliaceae (Honeysuckle family)
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 11/02: Nasal agents, e.g. decongestants
- A61P 13/00: Drugs for disorders of the urinary system
- A61P 13/02: of urine or of the urinary tract, e.g. urine acidifiers
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/04: Antipruritics
- A61P 17/10: Anti-acne agents
- A61P 27/16: Otologicals
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61K 47/18: Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided, among other things, is a method of treating or ameliorating an indication of non-mucosal topical tissue comprising periodically applying to such disease affected tissue a composition comprising: an effective amount of an appropriate composition of herbal bioactive comprising active(s) of one or more of Sambucus nigra, Centella asiatica or Echinacea purpurea, and an effective amount of a quaternary ammonium surfactant.

## Claims

### Claim 1

A method of treating or ameliorating an indication of non-mucosal topical tissue that is acne comprising periodically applying to such disease affected tissue a composition comprising
an effective amount of an appropriate composition of herbal extract(s) of one or more of Sambucus nigra, Centella asiatica or Echinacea purpurea, and
an effective amount of a quaternary ammonium surfactant.

### Claim 2 (depends on 1)

The method of claim 1, wherein the quaternary ammonium surfactant comprises a 1-alkylpyridinium salt, where alkyl is C8-C36.

### Claim 3

The method of claim one of the foregoing claims, further comprising applying to a portion of the tissue a film, patch or an adhesive solid formulation comprising appropriate composition of herbal extract(s) of one or more of Sambucus nigra, Centella asiatica or Echinacea purpurea.

### Claim 4 (depends on 1)

A method of claim 1, wherein the acne is acne urticata.

### Claim 5 (depends on 4)

The method of claim 4, further comprising applying to a portion of the tissue a film, patch or an adhesive solid formulation comprising appropriate composition of herbal bioactive extract(s) of one or more of Sambucus nigra, Centella asiatica or Echinacea purpurea.

### Claim 6 (depends on 4)

The method of claim 4, wherein the extract(s) of one or more of Sambucus nigra, Centella asiatica or Echinacea purpurea comprise an antiinflammatory amount.

### Claim 7 (depends on 5)

The method of claim 5, wherein the extract(s) of one or more of Sambucus nigra, Centella asiatica or Echinacea purpurea comprise an anti-inflammatory amount.

### Claim 8 (depends on 1)

The method of claim 1,
wherein Sambucus nigra extract is more than 50% to 90% by weight of the plant extract solids and Centella asiatica is 1% to less than 50% by weight of the plant extract solids, and
the surfactant is a 1-alkylpyridinium salt, where alkyl is C8-C36, the surfactant present in an amount from 0.01 to 5% of the formulation by weight.

### Claim 9 (depends on 4)

The method of claim 4, wherein the quaternary ammonium surfactant comprises a 1-alkylpyridinium salt, where alkyl is C8-C36.

### Claim 10 (depends on 4)

The method of claim 4,
wherein Sambucus nigra extract is more than 50% to 90% by weight of the plant extract solids and Centella asiatica is 1% to less than 50% by weight of the plant extract solids, and
the surfactant is a 1-alkylpyridinium salt, where alkyl is C8-C36, the surfactant present in an amount from 0.01 to 5% of the formulation by weight.