# US 8,771,752 B2 · Composition for preventing and treating fatty liver

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 8,771,752 B2
- Document ID: US8771752B2
- Status: Granted
- Kind: B2
- Application number: 13/300,793
- Filed: 2011-11-21
- Published: 2012-03-15
- Granted: 2014-07-08
- Earliest claimed: 2008-07-07
- Assignees: National Chung Hsing University
- Applicants: Frank Chiahung Mao; Wen-Ying Chen
- Inventors: Frank Chiahung Mao; Wen-Ying Chen
- Web page: https://patentgrep.com/patent/US8771752B2

## CPC

- A23L 33/16: Inorganic salts, minerals or trace elements
- A23L 33/19: Dairy proteins
- A61K 33/24: Heavy metals; Compounds thereof
- A61K 35/20: Milk; Whey; Colostrum
- A61K 36/06: Fungi, e.g. yeasts
- A61K 38/40: Transferrins, e.g. lactoferrins, ovotransferrins
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 3/06: Antihyperlipidemics
- A61K 2300/00: Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A composition for preventing and treating fatty liver is disclosed. The composition includes a lactoferrin and a trivalent chromium compound. The trivalent chromium compound of the present invention is selected from the group consisting of chromium (III) chloride hexahydrate, chromium (III) chloride, chromium (III) acetate, chromium (III) sulfate, chromium picolinate, chromium nicotinate, chromium GTF, chromium yeast extract, other inorganic salts of trivalent chromium, other organic salts of trivalent chromium, and combinations thereof. The composition of the present invention can provide a beneficial effect in preventing and treating fatty liver by effectively reducing multiple risk factors of fatty liver disease.

## Claims

### Claim 1

A method for improving liver function, wherein the method comprises administering to a subject in need thereof an effective amount of a composition comprising:
(a) a lactoferrin; and
(b) a trivalent chromium compound; wherein the trivalent chromium compound is selected from the group consisting of chromium (III) chloride hexahydrate, chromium (III) chloride, chromium (III) acetate, chromium (III) sulfate, chromium picolinate, chromium nicotinate, chromium GTF, chromium yeast extract, other inorganic salts of trivalent chromium, other organic salts of trivalent chromium, and combinations thereof,
wherein said effective amount comprises 8 mg/kg body weight (BW)/day of lactoferrin and 8 μg/kg BW/day of trivalent chromium, and
wherein the subject is a human.

### Claim 2 (depends on 1)

The method of claim 1, wherein the composition is used to reduce serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT).

### Claim 3 (depends on 1)

The method of claim 1, wherein the lactoferrin comes from unpurified milk or whey protein.

### Claim 4 (depends on 1)

The method of claim 1, wherein the lactoferrin is selected from the group consisting of cow lactoferrin, goat lactoferrin, unpurified cow milk, unpurified goat milk, and combinations thereof.

### Claim 5 (depends on 1)

The method of claim 1, wherein the trivalent chromium compound is selected from the group consisting of chromium (III) chloride hexahydrate, chromium (III) chloride, chromium (III) acetate, chromium (III) sulfate, chromium picolinate, chromium nicotinate, chromium GTF, chromium yeast extract, and combinations thereof.

### Claim 6 (depends on 1)

The method of claim 1, wherein the composition serves as an additive of a dairy product, which is selected from the group consisting of fresh milk of mammals, long-life milk, concentrated milk, fermented milk, cheese, and milk powder.

### Claim 7

A method for treating fatty liver, wherein the method comprises administering to a subject in need thereof an effective amount of a composition comprising:
(a) a lactoferrin; and
(b) a trivalent chromium compound; wherein the trivalent chromium compound is selected from the group consisting of chromium (III) chloride hexahydrate, chromium (III) chloride, chromium (III) acetate, chromium (III) sulfate, chromium picolinate, chromium nicotinate, chromium glucose tolerance factor (GTF), chromium yeast extract, other inorganic salts of trivalent chromium, other organic salts of trivalent chromium, and combinations thereof,
wherein said effective amount comprises 8 mg/kg body weight (BW)/day of lactoferrin and 8 μg/kg BW/day of trivalent chromium, and
wherein the subject is a human.

### Claim 8 (depends on 7)

The method of claim 7, wherein the lactoferrin comes from unpurified milk or whey protein.

### Claim 9 (depends on 7)

The method of claim 7, wherein the lactoferrin is selected from the group consisting of cow lactoferrin, goat lactoferrin, unpurified cow milk, unpurified goat milk, and combinations thereof.

### Claim 10 (depends on 7)

The method of claim 7, wherein the trivalent chromium compound is selected from the group consisting of chromium (III) chloride hexahydrate, chromium (III) chloride, chromium (III) acetate, chromium (III) sulfate, chromium picolinate, chromium nicotinate, chromium GTF, chromium yeast extract, and combinations thereof.

### Claim 11 (depends on 7)

The method of claim 7, wherein the composition serves as an additive of a dairy product, which is selected from the group consisting of fresh milk of mammals, long-life milk, concentrated milk, fermented milk, cheese, and milk powder.