# US 8,771,751 B2 · Metallic implant which is degradable in vivo

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- Number: US 8,771,751 B2
- Document ID: US8771751B2
- Status: Granted
- Kind: B2
- Application number: 13/211,921
- Filed: 2011-08-17
- Published: 2011-12-08
- Granted: 2014-07-08
- Earliest claimed: 1997-07-18
- Assignees: BIOTRONIK SE & Co. KG
- Applicants: Bernd Heublein; Gerd Hausdorf
- Inventors: Bernd Heublein; Gerd Hausdorf
- Web page: https://patentgrep.com/patent/US8771751B2

## CPC

- A61L 31/148: {Materials at least partially resorbable by the body}
- A61B 17/1204: {temporary occlusion}
- A61B 17/12099: {characterised by the location of the occluder}
- A61B 17/12104: {in an air passage}
- A61B 17/12109: {in a blood vessel}
- A61B 17/12131: {characterised by the type of occluding device}
- A61B 17/1214: {Coils or wires}
- A61B 17/12181: {formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices}
- A61B 17/866: {Material or manufacture}
- A61L 27/042: {Iron or iron alloys}
- A61L 27/047: {Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06}
- A61L 27/58: Materials at least partially resorbable by the body
- A61L 31/022: {Metals or alloys}
- A61B 17/12022: {Occluding by internal devices, e.g. balloons or releasable wires (plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20)}
- A61B 17/68: Internal fixation devices {, including fasteners and spinal fixators, even if a part thereof projects from the skin (bone staples A61B17/0642)}
- A61B 2017/00004: {(bio)absorbable, (bio)resorbable or resorptive}
- A61F 2/82: Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07)
- A61F 2002/30062: {(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive}
- A61F 2210/0004: bioabsorbable
- A61F 2310/00011: Metals or alloys
- A61F 2310/00017: Iron- or Fe-based alloys, e.g. stainless steel
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

The invention relates to a medical implant made of a metallic material. After fulfilling its temporary support function, the implant is degraded by corrosion at a predetermined rate. Negative long-term effects are thus avoided.

## Claims

### Claim 1

A device comprising a medical implant made from a metallic material degradable in vivo through corrosion,
wherein the material has a thickness and a composition consisting of an alloy having iron as its major constituent,
wherein the material contains 88-99.8% iron, 0.1-7% chromium, 0-3.5% nickel, and less than 5% other metals, and, optionally, up to 7% carbon,
wherein the implant is a vascular support in the form of a stent.

### Claim 2 (depends on 1)

The device of claim 1, wherein the material further contains up to 7% carbon.

### Claim 3 (depends on 1)

The device of claim 1, wherein the thickness of the material is selected with regard to the composition of the material in order to provide substantially complete degradation or corrosion of the device in vivo within from about 5 days to about 6 months.

### Claim 4 (depends on 1)

The device of claim 1, wherein the thickness of the material is selected with regard to the composition of the material in order to provide substantially complete degradation or corrosion of the device in vivo within from about 2 weeks to about 8 weeks.

### Claim 5 (depends on 1)

The device of claim 1, wherein the thickness of the material is selected with regard to the composition of the material in order to provide substantially complete degradation or corrosion of the device in vivo within from 6 months to 10 years.

### Claim 6 (depends on 1)

The device of claim 1, wherein the thickness of the material is selected with regard to the composition of the material in order to provide substantially complete degradation or corrosion of the device in vivo within from about 1 year to about 5 years.