# US 8,771,750 B2 · Delivery or removal of metals from biological systems

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- Number: US 8,771,750 B2
- Document ID: US8771750B2
- Status: Granted
- Kind: B2
- Application number: 11/639,105
- Filed: 2006-12-14
- Published: 2008-06-19
- Granted: 2014-07-08
- Earliest claimed: 2006-12-14
- Assignees: Savannah River Nuclear Solutions, LLC
- Applicants: David T. Hobbs; John C. Wataha; Jill Lewis; Regina L. W. Messer
- Inventors: David T. Hobbs; John C. Wataha; Jill Lewis; Regina L. W. Messer
- Web page: https://patentgrep.com/patent/US8771750B2

## CPC

- A61K 31/665: having oxygen as a ring hetero atom, e.g. fosfomycin
- A61K 33/24: Heavy metals; Compounds thereof
- A61K 33/242: Gold; Compounds thereof
- A61K 47/6923: {the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb}
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 19/00: Drugs for skeletal disorders
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A process for delivering and/or removing metal from a biological system by loading a titanate sorbent with a biometal either before introduction into the system for delivery to a site within the system or after introduction into the system for delivery to a site where there is an excess accumulation of metal and thereafter the sorbent is loaded at the site with the excess metal and is removed from the system.

## Claims

### Claim 1

A method for delivering selected metals or metal compounds having therapeutic treatment properties to a selected site in the biological systems of human and animal patients comprising the steps of:
a) selecting a biometal from the group consisting of metals and metal compounds known to have a beneficial effect for a patient when delivered to the selected site;
(b) loading a titanate sorbent with said biometal; and
(c) delivering the loaded sorbent to the selected site within said biological system whereby a portion of said loaded sorbent is absorbed at the site; and,
(d) removing excess loaded sorbent from said system.

### Claim 2 (depends on 1)

The method of claim 1 wherein the site is selected from the group consisting of bone, joints, and tumors in a human body.

### Claim 3 (depends on 1)

The method of claim 1 wherein the biological system is selected from the group consisting of an organ, the digestive system, urinary system, lymph, blood and respiratory system of a human body.

### Claim 4

A method for delivery of metals or metal compounds having therapeutic treatment properties to selected sites in a biological system of a human or animal patient where a health problem exists that is expected to beneficially respond to the deliver of said metals, said method comprising the steps of:
a) loading a selected therapeutic metal or metal compound onto a titanate sorbent selected from the group consisting of MST having a general chemical formula of HNA Ti2O5xH2O where x˜2-4 and APT having a general chemical formula of HvNawTisO5(xH2O)[yHzO2] where v+w=2 and z=O to 2;
b) delivering the titanate sorbent to the selected site of a patient whereby the metal that accumulates at the site provides a therapeutic treatment; and
c) removing the loaded sorbent from the system.

### Claim 5 (depends on 4)

The method of claim 4 wherein step b) is performed by oral ingestion by the patient.

### Claim 6 (depends on 4)

The method of claim 4 wherein step b) is performed by injection into the tissue of the selected site.

### Claim 7 (depends on 4)

The method of claim 4 wherein the therapeutic metal includes gold, said gold being the organogold compound auranofin based on Au(I) and the loading step is performed by the steps of dissolving auranofin in ethanol in a phosphate buffered saline solution with MST or APT, tumbling the solution in a centrifuge tube, and centrifuging the suspension to produce separable layers of the solution with loaded MST or APT depleted in the therapeutic metal and the MST and APT solids loaded within the therapeutic metal.

### Claim 8 (depends on 4)

The method of claim 4 wherein:
i) the titanate sorbent is loaded with a metal selected from the group consisting of gold, platinum and compounds thereof;
ii) said loaded sorbent is delivered to the biological system of a patient selected from the group consisting of human and animal patients;
iii) the titanate sorbent is amorphous peroxotitanate (APT);
iv) the selected site is the site of a tumor; and
v) the method of delivery is by injection.