# US 8,771,745 B2 · Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof

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- Number: US 8,771,745 B2
- Document ID: US8771745B2
- Status: Granted
- Kind: B2
- Application number: 13/596,904
- Filed: 2012-08-28
- Published: 2013-01-17
- Granted: 2014-07-08
- Earliest claimed: 2008-10-27
- Assignees: Allergan, Inc.
- Applicants: Michael R. Robinson; Hui Liu; Patrick M. Hughes; Lon T. Spada; Alazar N. Ghebremeskel
- Inventors: Michael R. Robinson; Hui Liu; Patrick M. Hughes; Lon T. Spada; Alazar N. Ghebremeskel
- Web page: https://patentgrep.com/patent/US8771745B2

## CPC

- A61L 31/06: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)}
- A61K 9/0048: {Eye, e.g. artificial tears}
- A61K 9/0051: {Ocular inserts or implants}
- A61K 9/1647: {Polyesters, e.g. poly(lactide-co-glycolide)}
- A61K 9/204: {Polyesters, e.g. poly(lactide-co-glycolide)}
- A61K 31/216: of acids having aromatic rings, e.g. benactizyne, clofibrate
- A61K 31/557: Eicosanoids, e.g. leukotrienes {or prostaglandins}
- A61K 31/5575: having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- A61P 27/06: Antiglaucoma agents or miotics
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Biocompatible, bioerodible implants and microspheres include latanoprost and a biodegradable polymer effective, when placed intraocular (such as into the subtenon space) to treat glaucoma.

## Claims

### Claim 1

A method of treating glaucoma, the method comprising anterior sub-tenon administration to a patient with glaucoma of a 50-μl pharmaceutical composition consisting of:
(a) a plurality of microspheres made from a PLGA and/or PLA;
(b) 1242 micrograms of latanoprost contained by the microspheres, and;
(c) 50 μl of a high viscosity hyaluronic acid, the high viscosity hyaluronic acid corresponding to a gel formed of 18 mg of a cross-linked hyaluronic acid in 1 ml of phosphate buffer at pH 7.2, the cross-linked hyaluronic acid having an average molecular weight of about 2 million Daltons, thereby treating the glaucoma.