# US 8,771,731 B2 · Antimicrobial nanoemulsion compositions and methods

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- Number: US 8,771,731 B2
- Document ID: US8771731B2
- Status: Granted
- Kind: B2
- Application number: 11/506,442
- Filed: 2006-08-18
- Published: 2011-03-24
- Granted: 2014-07-08
- Earliest claimed: 1999-04-28
- Assignees: The Regents of the University of Michigan
- Applicants: James R. Baker, Jr.; Tarek Hamouda; Amy Shih; Andrzej Myc
- Inventors: James R. Baker, Jr.; Tarek Hamouda; Amy Shih; Andrzej Myc
- Web page: https://patentgrep.com/patent/US8771731B2

## CPC

- A61K 9/1075: {Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers (A61K9/0026 takes precedence)}
- A61K 8/062: {Oil-in-water emulsions}
- A61K 31/14: Quaternary ammonium compounds, e.g. edrophonium, choline (betaines A61K31/205)
- A61K 31/522: having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61Q 17/005: {Antimicrobial preparations}
- A61Q 19/00: Preparations for care of the skin
- B82Y 5/00: Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
- A61K 2800/21: Emulsions characterized by droplet sizes below 1 micron
- A61K 2800/413: Nanosized, i.e. having sizes below 100 nm
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- B82Y: SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES

## Abstract

The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods and compositions for decreasing the infectivity of pathogenic organisms in foodstuffs.

## Claims

### Claim 1

An oil-in-water nanoemulsion, consisting essentially of:
a) 3-15% by volume surfactant;
b) 3-15% by volume ethanol or glycerol;
c) 50-80% by volume oil;
d) about 1% by volume cetylpyridinium chloride;
e) distilled water; and
f) an interaction enhancer;
or a dilution thereof.

### Claim 2 (depends on 1)

The nanoemulsion of claim 1, wherein said nanoemulsion has a mean particle size less than 0.5 microns.

### Claim 3 (depends on 1)

The nanoemulsion of claim 1, wherein said nanoemulsion has a mean particle size of 0.2 to 0.8 microns.

### Claim 4 (depends on 1)

The nanoemulsion of claim 1, wherein said surfactant comprises polyoxyethylenesorbitane monolaurate.

### Claim 5 (depends on 1)

The nanoemulsion of claim 1, wherein said surfactant comprises polyoxyethylenesorbitan monooleate.

### Claim 6 (depends on 1)

The nanoemulsion of claim 1, wherein said surfactant is 5% by volume.

### Claim 7 (depends on 1)

The nanoemulsion of claim 1, wherein said ethanol or glycerol is ethanol.

### Claim 8 (depends on 1)

The nanoemulsion of claim 1, wherein said ethanol or glycerol is glycerol.

### Claim 9 (depends on 1)

The nanoemulsion of claim 1, wherein said ethanol or glycerol is 8% by volume.

### Claim 10 (depends on 1)

The nanoemulsion of claim 1, wherein said oil is 64% by volume.

### Claim 11 (depends on 1)

The nanoemulsion of claim 1, wherein said oil is soybean oil.

### Claim 12 (depends on 1)

The nanoemulsion of claim 1, wherein said distilled water is pyrogen free.

### Claim 13 (depends on 1)

The nanoemulsion of claim 1, wherein said interaction enhancer is EDTA.

### Claim 14 (depends on 1)

The nanoemulsion of claim 1, wherein said dilution is a 10% dilution of said nanoemulsion in distilled water.

### Claim 15

An oil-in-water nanoemulsion consisting essentially of:
a) a surfactant;
b) ethanol;
c) cetylpyridinium chloride;
d) oil;
e) distilled water; and
f) EDTA.

### Claim 16

A nanoemulsion produced by the method of:
a) combining an oil, a solvent, a surfactant, cetylpyridinium chloride, an interaction enhancer, and distilled water under conditions such that a nanoemulsion is generated; and
b) placing said nanoemulsion in a pharmaceutically acceptable container and storing for at least one week.