# US 8,771,726 B2 · Nail patch

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- Number: US 8,771,726 B2
- Document ID: US8771726B2
- Status: Granted
- Kind: B2
- Application number: 12/310,167
- Filed: 2007-07-06
- Published: 2009-12-31
- Granted: 2014-07-08
- Earliest claimed: 2006-08-28
- Assignees: Hisamitsu Pharmaceutical Co., Inc.
- Applicants: Arata Toshimitsu; Naoko Matsuda; Toshihiro Kogure; Kazuya Ishida
- Inventors: Arata Toshimitsu; Naoko Matsuda; Toshihiro Kogure; Kazuya Ishida
- Web page: https://patentgrep.com/patent/US8771726B2

## CPC

- A61K 31/137: Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61P 17/00: Drugs for dermatological disorders
- A61P 31/10: Antimycotics
- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61K 47/14: Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present subject matter provides a nail patch comprising a backing layer and a pressure-sensitive adhesive layer disposed on at least one side of the backing layer, wherein the pressure-sensitive adhesive layer comprises a pressure-sensitive adhesive base, terbinafine and/or a pharmacologically acceptable salt thereof, and sodium acetate and/or sorbitan monolaurate as a solubilizer.

## Claims

### Claim 1

A nail patch comprising:
a backing layer; and
a pressure-sensitive adhesive layer disposed on at least one side of the backing layer, wherein the pressure-sensitive adhesive layer comprises:
a pressure-sensitive adhesive base comprising an acrylic pressure-sensitive adhesive,
terbinafine and/or a pharmacologically acceptable salt thereof present in an amount of from 5 to 50% by mass based on total mass of the pressure-sensitive adhesive layer, and
a solubilizer comprising sodium acetate and sorbitan monolaurate.

### Claim 2 (depends on 1)

The nail patch according to claim 1, wherein the acrylic pressure-sensitive adhesive is an acrylic copolymer having a hydroxyl or carboxylic acid group.

### Claim 3 (depends on 1)

The nail patch according to claim 1, wherein the pressure-sensitive adhesive layer comprises 5 to 30% by mass of terbinafine and/or a pharmacologically acceptable salt thereof based on total mass of the pressure-sensitive adhesive layer.

### Claim 4 (depends on 1)

The nail patch according to claim 1, wherein the pharmacologically acceptable salt of terbinafine is terbinafine hydrochloride.

### Claim 5 (depends on 1)

The nail patch according to claim 1, wherein the pressure-sensitive adhesive layer further comprises a plasticizer.

### Claim 6

A nail patch comprising:
a backing layer; and
a pressure-sensitive adhesive layer disposed on at least one side of the backing layer, wherein the pressure-sensitive adhesive layer comprises:
a pressure-sensitive adhesive base comprising an acrylic pressure-sensitive adhesive,
terbinafine and/or a pharmacologically acceptable salt thereof present in an amount of from 5 to 50% by mass based on total mass of the pressure-sensitive adhesive layer, and
a solubilizer consisting of sodium acetate and sorbitan monolaurate.