Back to results
US 8,771,714 B2Granted
Systems and methods for in vivo measurement of interstitial biological activity, processes and/or compositions
AssigneeMUSC Foundation for Research Development
InventorsFrancis G. Spinale, Robert Stroud, Michael Looper, Anne Deschamps
Life of this patent
Estimating the term…
Abstract
Provided are systems and methods for detecting and/or measuring in vivo interstitial biological activity, processes, and or compounds in human or animal subjects.
Claims29
A method of real-time in vivo monitoring of a biological process, comprising:
- identifying a compound of interest that is located in the non-cardiac interstitium of the subject, wherein the activity or presence of the compound is related to the in vivo biological process being monitored;
- positioning a probe within the non-cardiac interstitium of the subject;
- infusing the interstitium of the subject with a fluorogenic substrate specific for the compound of interest wherein the substrate is infused therethrough the probe;
- receiving interstitial fluid from the subject with the probe, wherein the interstitial fluid comprises the substrate;
- and
- detecting the received substrate to monitor the biological process in the subject.
3 more elements
Dependencies are inferred from the claim text.