# US 8,771,712 B2 · Topical administration of acyclovir

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- Number: US 8,771,712 B2
- Document ID: US8771712B2
- Status: Granted
- Kind: B2
- Application number: 12/300,090
- Filed: 2007-05-02
- Published: 2009-05-07
- Granted: 2014-07-08
- Earliest claimed: 2006-05-09
- Assignees: Emisphere Technologies, Inc.
- Applicants: Steven Dinh; Puchun Liu; Ihor Shevchuk
- Inventors: Steven Dinh; Puchun Liu; Ihor Shevchuk
- Web page: https://patentgrep.com/patent/US8771712B2

## CPC

- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61P 31/12: Antivirals
- A61K 47/183: {Amino acids, e.g. glycine, EDTA or aspartame}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention provides a topical composition comprising (a) at least one delivery agent compound and (b) a acyclovir compound. Methods of treatment, and methods of preparing the topical composition are also provided.

## Claims

### Claim 1

A pharmaceutical composition comprising
(a) about 1% to about 10% by weight of acyclovir or a salt thereof;
(b) a vehicle for topical delivery comprising alcohol and water at a ratio of 1:1 to 7:3; and
a delivery agent compound which is N-(8-[2-hydroxybenzoyl]amino)caprylic acid or a salt thereof;
wherein the pharmaceutical composition is a topical pharmaceutical composition.

### Claim 2 (depends on 1)

The pharmaceutical composition of claim 1, wherein the delivery agent compound is a sodium salt of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid.

### Claim 3 (depends on 1)

The pharmaceutical composition of claim 1, wherein the vehicle for topical delivery further comprises polyethylene glycol.

### Claim 4 (depends on 1)

The pharmaceutical composition of claim 1, wherein the acyclovir or salt thereof component epidermal flux enhancement factor is 4 or higher.

### Claim 5 (depends on 1)

The pharmaceutical composition of claim 1, further comprising one or more additional active agents selected from anti-allergic medications, glucocorticoids, corticosteroids, anti-inflammatory agents, pain relievers, local anesthetics, and combinations thereof.

### Claim 6 (depends on 5)

The pharmaceutical composition of claim 5, where the one or more additional active agents is selected from oxatamide, betamethasone, valerate, dexamethasone, triamcinolone acetonide, clobetasone butyrate, hydrocortisone, triamcinolone, flurbiprofen, ketorolace, lidocaine, benzocaine, articaine, chlorprocaine, cocaine, dydloninem, proparacaine, mepivacaine, prilocalne, procaine, tetracaine, pramoxin, and combinations thereof.

### Claim 7 (depends on 1)

The pharmaceutical composition of claim 1, wherein the alcohol is ethanol.