# US 8,771,674 B2 · Oligosaccharide composition for treating skin diseases

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- Number: US 8,771,674 B2
- Document ID: US8771674B2
- Status: Granted
- Kind: B2
- Application number: 13/988,990
- Filed: 2011-11-21
- Published: 2013-09-26
- Granted: 2014-07-08
- Earliest claimed: 2010-11-23
- Assignees: Nestec S.A.
- Applicants: Norbert Sprenger
- Inventors: Norbert Sprenger
- Web page: https://patentgrep.com/patent/US8771674B2

## CPC

- A61K 31/702: Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A23L 33/21: Addition of substantially indigestible substances, e.g. dietary fibres
- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A61K 31/7016: Disaccharides, e.g. lactose, lactulose (lactobionic acid A61K31/7032)
- A61K 35/741: Probiotics (probiotic yeast, e.g. saccharomyces A61K36/06)
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 17/00: Drugs for dermatological disorders
- A61P 37/00: Drugs for immunological or allergic disorders
- A61P 37/02: Immunomodulators
- C12N 1/20: Bacteria; Culture media therefor
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The invention discloses a composition comprising at least one N-acetyl-lactosamine, at least one sialylated oligosaccharide and at least one fucosylated oligosaccharide, for use in the prevention and/or treatment of skin conditions and skin diseases. Preferably said composition is a starter infant formula. Said skin disease is in particular atopic dermatitis.

## Claims

### Claim 1

A method for the prevention and/or treatment of skin conditions and skin diseases comprising the step of administering a composition comprising at least one chemically synthesized N-acetyl-lactosamine, at least one sialylated oligosaccharide and at least one fucosylated oligosaccharide to an individual in need of same, the sialylated oligosaccharide comprising 3′-sialyllactose and 6′-sialyllactose, and a ratio of 3′-sialyllactose to 6′-sialyllactose being in the range between 5:1 and 1:2 on a weight basis.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the N-acetyl-lactosamine is selected from the group consisting of lacto-N-tetraose and lacto-N-neotetraose.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the fucosylated oligosaccharide is selected from the group consisting of 2′-fucosyllactose, 3-fucosyllactose, difucosyllactose, lacto-N-fucopentaoses, lacto-N-difucohexaose I, fucosyllacto-N-hexaose, Difucosyllacto-N-hexaose I and Difucosyllacto-N-neohexaose II.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the composition comprises at least one probiotic bacterial strain.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the composition comprises at least one prebiotic.

### Claim 6 (depends on 1)

The method according to claim 1, the composition is selected from the group consisting of a starter infant formula, an infant formula, a follow-on formula, a baby food formula, an infant cereals formula and a growing-up milk.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the individual is a healthy infants and healthy young children.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the composition is administered before and/or during a weaning period.

### Claim 9 (depends on 1)

The method according to claim 1, wherein the individual has experienced at least one episode of the skin diseases.

### Claim 10 (depends on 1)

The method according to claim 1, wherein the individual has experienced at least one episode of skin dehydration and/or skin rash, roughness and/or dryness.

### Claim 11 (depends on 1)

The method according to claim 1, wherein the individual has experienced at least one episode of atopic dermatitis.

### Claim 12

A method for the enhancement of the oral tolerance to allergens in an individual comprising the step of administering to the individual a composition comprising at least one N-acetyl lactosamine, at least one sialylated oligosaccharide and at least one fucosylated oligosaccharide, as a synthetic nutritional agent, the sialylated oligosaccharide comprising 3′-sialyllactose and 6′-sialyllactose, and a ratio of 3′-sialyllactose to 6′-sialyllactose being in the range between 5:1 and 1:2 on a weight basis.

### Claim 13 (depends on 11)

The method according to claim 11, wherein the composition is a supplement.