# US 8,771,652 B2 · Methods of blocking ultraviolet radiation and promoting skin growth using terpenes and terpenoids > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,771,652 B2 - Document ID: US8771652B2 - Status: Granted - Kind: B2 - Application number: 12/807,979 - Filed: 2010-09-17 - Published: 2011-06-30 - Granted: 2014-07-08 - Earliest claimed: 2009-09-17 - Assignees: New York University; BioKeys for Flavors, LLC - Applicants: Ivica Labuda; Fredric Jay Burns - Inventors: Ivica Labuda; Fredric Jay Burns - Web page: https://patentgrep.com/patent/US8771652B2 ## CPC - A61K 31/122: having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin - A61K 8/31: Hydrocarbons - A61K 8/35: Ketones, e.g. benzophenone - A61K 8/9789: Magnoliopsida [dicotyledons] - A61K 8/9794: Liliopsida [monocotyledons] - A61K 31/015: carbocyclic - A61K 31/12: Ketones - A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like - A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations - A61Q 19/08: Anti-ageing preparations - A61K 48/00: Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract The present invention provides methods of treating humans and animals with terpenes and terpenoids in order to rejuvenate the skin and increase the protective layer against irradiation by ultraviolet radiation (UVR). More specifically it provides terpenes and terpenoids as ingredients that work as persistent UVR blockers. Terpenes and terpenoid compounds support the growth of skin, skin tissue and keratinocytes and additional UVR-blocking by reason of increased stratum corneum thickness and loricrin content. Both terpenes and terpenoids may be applied topically or orally at oral or topical concentrations from about 6 mg to about 600 mg per kilogram of body weight per day effective to stimulate growth of the skin layer and prevent damage from ultraviolet radiation (UVR). ## Claims ### Claim 1 A method of increasing the amount of ultraviolet radiation (UVR) that the skin can block or absorb comprising administering a terpene wherein the terpene is administered prior to exposure to UVR. ### Claim 2 (depends on 1) A method according to claim 1 wherein the terpene is administered at least one time per day. ### Claim 3 (depends on 1) A method according to claim 1 wherein the terpene is selected from the group consisting of beta-damascenone, nootkatone, and d-limonene. ### Claim 4 (depends on 1) A method according to claim 1 wherein the terpene is administered orally. ### Claim 5 (depends on 1) A method according to claim 1 wherein the terpene is administered topically. ### Claim 6 (depends on 1) A method according to claim 1 wherein the terpene is administered in a dosage and in amounts sufficient to reduce the amount of cutaneous inflammation and erythema present in the skin of subjects receiving the terpene compared to the amount of cutaneous inflammation and erythema present in the skin of subjects not receiving the terpene when both subjects or both sets of subjects are exposed to the same dosage of UVR. ### Claim 7 (depends on 1) A method according to claim 1 wherein the terpene is administered in a dosage and in amounts sufficient to increase epidermal cell proliferation and increase keratin production in the skin of subjects receiving the terpene compared to the amount of epidermal cell proliferation and keratin production present in the skin of subjects not receiving the terpene when both subjects or both sets of subjects are exposed to the same dosage of UVR. ### Claim 8 (depends on 1) A method according to claim 1 wherein the terpene is administered in a dosage and in amounts sufficient to alter the expression of one or more gene products selected from the group consisting of NFKappaB, COX1, COX2, MAPKS, PGE2, ODC, protein kinase C, INOS, PI3-AKT, TNF-A, AP1, NRF2, KEAP1 and IKappa kinase. ### Claim 9 A method of increasing the amount of ultraviolet radiation (UVR) that the skin can block or absorb comprising orally administering a terpene. ### Claim 10 A method of increasing the amount of ultraviolet radiation (UVR) that the skin can block or absorb comprising administering a terpene in a dosage and in amounts sufficient to increase epidermal cell proliferation and increase keratin production in the skin of subjects receiving the terpene compared to the amount of epidermal cell proliferation and keratin production present in the skin of subjects not receiving the terpene when both subjects or both sets of subjects are exposed to the same dosage of UVR. ### Claim 11 A method of increasing the amount of ultraviolet radiation (UVR) that the skin can block or absorb comprising administering a terpene in a dosage and in amounts sufficient to alter the expression of one or more gene products selected from the group consisting of NFKappaB, COX1, COX2, MAPKS, PGE2, ODC, protein kinase C, INOS, PI3-AKT, TNF-A, AP1, NRF2, KEAP1 and IKappa kinase. ### Claim 12 (depends on 1) A method of increasing the amount of ultraviolet radiation (UVR) that the skin can block or absorb according to claim 1 wherein the terpene is a hydrocarbon having an isoprene group. ### Claim 13 (depends on 1) A method of increasing the amount of ultraviolet radiation (UVR) that the skin can block or absorb according to claim 1 wherein the terpene is administered orally at least one hour prior to exposure to the sun or UV radiation.