# US 8,771,513 B2 · Regeneratable filter for extracorporal treatment of liquids containing particles and use thereof

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 8,771,513 B2
- Document ID: US8771513B2
- Status: Granted
- Kind: B2
- Application number: 12/282,407
- Filed: 2007-03-14
- Published: 2011-04-28
- Granted: 2014-07-08
- Earliest claimed: 2006-03-14
- Assignees: Adexter GmbH
- Applicants: Hans-Werner Heinrich; Peter Kruschke
- Inventors: Hans-Werner Heinrich; Peter Kruschke
- Web page: https://patentgrep.com/patent/US8771513B2

## CPC

- A61M 1/3472: {with treatment of the filtrate}
- A61M 1/3475: {with filtrate treatment agent in the same enclosure as the membrane}
- A61M 1/3486: {Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents}
- A61M 1/3616: {Batch-type treatment}
- A61M 1/3643: {Priming, rinsing before or after use}
- A61M 1/365: {through membranes, e.g. by inverted trans-membrane pressure [TMP]}
- B01D 63/02: Hollow fibre modules
- B01D 65/02: Membrane cleaning or sterilisation {; Membrane regeneration}
- A61M 2205/7554: with means for unclogging or regenerating filters
- A61M 2205/7581: with means for switching over to a fresh filter on clogging or saturation
- B01D 2313/32: Intermediate chambers
- B01D 2313/40: Adsorbents within the flow path
- B01D 2321/04: Backflushing
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)

## Abstract

The invention relates to a regeneratable filtering and adsorbing system, combining the properties of membrane filtration with those of particle-based adsorption in a closed housing.

## Claims

### Claim 1

A filter system for membrane-separated and adsorptive treatment of a liquid containing at least one target substance to be filtered, comprising a housing having an upper end, a lower end, an inlet opening at said upper end of said housing, at least a first three-directional valve connected outside said housing to said inlet opening, an outlet opening at said lower end of said housing, at least a second three-directional valve connected outside said housing to said outlet opening, a side opening in said housing between said upper end and said lower end, and at least a third three-directional valve connected outside said housing to said side opening, said housing containing a plurality of hollow fibre membranes with pores, said hollow fibre membranes arranged so as to form a reaction vessel inside said housing but not touching said housing, resulting in creation of an intra-luminal area inside said reaction vessel and an extra-luminal area between the hollow fibre membranes and said housing, said extra-luminal area capable of being filled with at least one adsorber material, with said hollow fibre membranes arranged in such a way that said inlet opening at said upper end of said housing opens into said reaction vessel, and at the bottom of said reaction vessel a screen, said screen creating a liquid area between said lower end of said housing and said screen, with said side opening in said housing being located below said screen and above said lower end, being arranged in such a way that regeneration of said adsorber material by reverse fluid flow is possible.

### Claim 2 (depends on 1)

A filter system according to claim 1, wherein the filter system comprises at least one housing and at least one reaction vessel.

### Claim 3 (depends on 1)

A filter system according to claim 1, wherein the extra-luminal area holds at least one adsorber material comprised of components.

### Claim 4 (depends on 3)

A filter system according to claim 3, wherein the diameter of the components of the adsorber material is larger than the pore diameter of the hollow fibre membranes.

### Claim 5 (depends on 4)

A filter system according to claim 4, wherein the adsorber material used therein has been functionalised.

### Claim 6 (depends on 5)

A filter system according to claim 5, wherein proteins which specifically bind a target substance are used for the specific functionalisation.

### Claim 7 (depends on 1)

A filter system according to claim 1, wherein the extra-luminal area comes into direct contact with the adsorber material and at least one target substance is bound to the adsorber material.

### Claim 8 (depends on 1)

A filter system according to claim 1, wherein the extra-luminal area depleted of at least one target substance is combined with the intra-luminal area via the second three-directional valve connected to the outlet opening and/or the third three-directional valve connected to the side opening.

### Claim 9 (depends on 1)

A filter system according to claim 1, wherein said regeneration occurs through the introduction of a cleansing liquid into the extra-luminal area by way of the side opening, said cleansing liquid removing at least one target substance from the adsorber material, and the extraction of the cleansing liquid and at least one target substance from the inlet opening via the first three-directional valve connected to the inlet opening.