# US 8,771,343 B2 · Medical devices with selective titanium oxide coatings > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,771,343 B2 - Document ID: US8771343B2 - Status: Granted - Kind: B2 - Application number: 11/763,770 - Filed: 2007-06-15 - Published: 2008-01-03 - Granted: 2014-07-08 - Earliest claimed: 2006-06-29 - Assignees: Boston Scientific Scimed, Inc. - Applicants: Jan Weber; Liliana Atanasoska; James Lee Shippy, III; Edward E. Parsonage - Inventors: Jan Weber; Liliana Atanasoska; James Lee Shippy, III; Edward E. Parsonage - Web page: https://patentgrep.com/patent/US8771343B2 ## CPC - A61F 2/82: Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07) - A61F 2/91: made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes - A61L 31/088: {Other specific inorganic materials not covered by A61L31/084 or A61L31/086} - A61L 31/10: Macromolecular materials - A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} - A61F 2002/30322: {differing in surface structures} - A61F 2250/0026: differing in surface structures - A61F 2250/0056: differing in wettability, e.g. in hydrophilic or hydrophobic behaviours - A61F 2310/00616: Coating made of titanium oxide or hydroxides - A61F 2310/0097: Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics - A61L 2300/00: Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices - B05D 1/32: using means for protecting parts of a surface not to be coated, e.g. using stencils, resists - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - B05D: PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL (conveying articles or workpieces through baths of liquid B65G, e.g. B65G49/02) ## Abstract Medical devices, such as endoprostheses, and methods of making the devices are described. In some embodiments, a medical device includes a body of interconnected bands and connectors forming an elongated tubular structure having an inner luminal wall surface and an outer abluminal wall surface and defining a central lumen or passageway. The inner luminal wall surface and side wall surface of the bands and connectors forming transverse passageways through the elongated tubular structure can bear a coating of hydrophilic material and the outer abluminal wall surface of the tubular structure can bear a coating of hydrophobic material. ## Claims ### Claim 1 A medical device comprising: an elongated tubular structure having an inner luminal wall surface, an outer abluminal wall surface, and side wall surfaces extending therebetween, a first coating on at least one or more regions of the luminal wall surface and/or the side wall surfaces comprising a material comprising titanium (+y) oxide (−x), a second coating on at least one or more regions of the abluminal wall surface comprising the material comprising the titanium (+y) oxide (−x), the material in one of the first coating and the second coating being hydrophobic and the one of the first coating and the second coating being hydrophobic, and the material in another of the first coating and the second coating being hydrophilic and the other one of the first coating and the second coating being hydrophilic, and a layer of organic compound over the first and second coatings. ### Claim 2 (depends on 1) The medical device of claim 1, wherein the first coating is hydrophilic and the second coating is hydrophobic. ### Claim 3 (depends on 2) The medical device of claim 2, wherein the first coating is superhydrophilic. ### Claim 4 (depends on 2) The medical device of claim 2, wherein the second coating further comprises a biomolecule and a polymer. ### Claim 5 (depends on 1) The medical device of claim 1, wherein the first coating is hydrophobic and the second coating is hydrophilic. ### Claim 6 (depends on 5) The medical device of claim 5, wherein the second coating is superhydrophilic. ### Claim 7 (depends on 1) The medical device of claim 1, wherein the first coating covers the luminal wall surface. ### Claim 8 (depends on 5, 7) The medical device of claim 5 or claim 7, wherein the first coating further covers the side wall surfaces. ### Claim 9 (depends on 1) The medical device of claim 1, wherein the second coating covers the abluminal wall surface. ### Claim 10 (depends on 1) The medical device of claim 1, wherein the second coating further comprises a biomolecule. ### Claim 11 (depends on 1) The medical device of claim 1, wherein the first coating further comprises a biomolecule. ### Claim 12 (depends on 11) The medical device of claim 11, wherein the first coating further comprises a polymer. ### Claim 13 (depends on 1) The medical device of claim 1, wherein the first coating and the second coating comprise phosphorus. ### Claim 14 (depends on 1) The medical device of claim 1, wherein one of the first coating and the second coating is porous. ### Claim 15 (depends on 14) The medical device of claim 14, wherein another of the first coating and the second coating is smooth. ### Claim 16 (depends on 14) The medical device of claim 14 further comprising biomolecules in pores of the one of the first coating and the second coating. ### Claim 17 (depends on 1) The medical device of claim 1, wherein the material comprises a crystal. ### Claim 18 (depends on 1) The medical device of claim 1, wherein the material is photoactive. ### Claim 19 (depends on 1) The medical device of claim 1, wherein the material in a first selectable state is hydrophilic and the material in a second selectable state is hydrophobic. ### Claim 20 (depends on 19) The medical device of claim 19, wherein the material is selected between the first state and the second state by exposure to UV light. ### Claim 21 (depends on 19) The medical device of claim 19, wherein the material is selected between the first state and the second state by wet-rubbing.