# US 8,771,310 B2 · Anti-no-reflow guide wire for vascular interventional procedures > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,771,310 B2 - Document ID: US8771310B2 - Status: Granted - Kind: B2 - Application number: 12/514,189 - Filed: 2008-05-28 - Published: 2010-02-11 - Granted: 2014-07-08 - Earliest claimed: 2007-05-31 - Assignees: Adenopaint, LLC - Applicants: Mervyn B. Forman; Edwin K. Jackson; Jianying Zhang; Zaichuan Mi - Inventors: Mervyn B. Forman; Edwin K. Jackson; Jianying Zhang; Zaichuan Mi - Web page: https://patentgrep.com/patent/US8771310B2 ## CPC - A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} - A61L 31/10: Macromolecular materials - A61L 2300/416: Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus - A61L 2300/432: Inhibitors, antagonists (A61L2300/402 - A61L2300/43 take precedence) - A61L 2300/80: characterised by a special chemical form - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract The present invention relates to compositions and methods for improving outcomes in vascular interventional procedures. In particular, the present invention relates to compositions and methods for improving outcomes in vascular interventional procedures using an anti-no-reflow guide wire that attenuates the “no-reflow” phenomenon that is associated with negative outcomes. ## Claims ### Claim 1 A medical device for attenuating no-reflow phenomenon, comprising a cardiac guide wire; a polymer or a monomer formed from a polyisocyanate and adenosine, coating at least a portion of the wire; and optionally, free adenosine, not covalently linked to the polymer or the monomer, but entrapped in the polymer or monomer, wherein the polymer or monomer is configured to release adenosine to the blood vessels upon contact between the polymer or monomer and a body fluid, thus causing dilation of blood vessels within five minutes of release. ### Claim 2 (depends on 1) The medical device of claim 1 wherein the polymer is formed by the reaction of: a monomer formed by reacting a polyisocyanate with a polyol, with a monomer formed by reacting a polyisocyanate with adenosine. ### Claim 3 (depends on 1) The medical device of claim 1 wherein the polyisocyanate is lysine diisocyanate or a lysine diisocyanate ester. ### Claim 4 (depends on 1) The medical device of claim 1 wherein the polymer or a monomer is formed by reacting a polyisocyanate, a polyol, and adenosine. ### Claim 5 (depends on 1) The medical device of claim 1 wherein the polymer or monomer is formed by reacting adenosine, lysine diisocyanate or a lysine diisocyanate ester, and glycerol. ### Claim 6 (depends on 1) The medical device of claim 1, wherein the polymer comprises units of the formula (I): wherein R′, R″, and R′″ represent the same or a different unit having the formula (II): such that the unit of formula (II) can bond to formula (I) through any combination of the bonding sites A, B, and C; and each R is independently a unit having the formula: ### Claim 7 (depends on 1) The medical device of claim 1 wherein the polymer comprises a monomer having the formula: wherein each R unit is independently selected from a unit having the formula: ### Claim 8 (depends on 1) The medical device of claim 1 wherein the polymer comprises a monomer having the formula: ### Claim 9 (depends on 1) The medical device of claim 1 wherein the polymer comprises the formula: wherein R3 has the formula: and wherein each R is independently a unit having the formula: ### Claim 10 A medical device for attenuating no-reflow phenomenon, comprising a cardiac guide wire, wherein at least a portion of the wire is coated with a polymer formed by the reaction of an LDI-Adenosine monomer with an LDI-Glycerol monomer, wherein the device is configured to release adenosine to the blood vessels upon contact with a body fluid, thus causing dilation of blood vessels. ### Claim 11 (depends on 10) The medical device of claim 10, further comprising free adenosine, not covalently linked to monomer or polymer, but entrapped in the polymer. ### Claim 12 (depends on 10) The medical device of claim 10, wherein the LDI-Adenosine monomer has the formula: ### Claim 13 (depends on 10) The medical device of claim 10, wherein the LDI-Glycerol monomer has the formula: ### Claim 14 (depends on 10) The medical device of claim 10 wherein the LDI-Glycerol monomer is provided by reaction of glycerol with excess lysine diisocyanate or a lysine diisocyanate ester. ### Claim 15 (depends on 10) The medical device of claim 10, wherein the LDI-Adenosine monomer is provided by reaction of excess adenosine with lysine diisocyanate or a lysine diisocyanate ester. ### Claim 16 A medical device for attenuating no-reflow phenomenon, comprising a cardiac guide wire, wherein at least a portion of the wire is coated with a polymer formed by polymerization of an Adenosine-LDI-Cysteine monomer, wherein the device is configured to release adenosine to the blood vessels upon contact with a body fluid, thus causing dilation of blood vessels. ### Claim 17 (depends on 16) The medical device of claim 16, further comprising free adenosine, not covalently linked to monomer or polymer, but entrapped in the polymer. ### Claim 18 (depends on 16) The medical device of claim 16, wherein the Adenosine-LDI-Cysteine monomer is provided by reaction of an Adenosine-LDI monomer with a cysteine ester and excess adenosine. ### Claim 19 (depends on 18) The medical device of claim 18, wherein the LDI-Adenosine monomer is provided by reaction of excess lysine diisocyanate or a lysine diisocyanate ester with adenosine. ### Claim 20 (depends on 18) The medical device of claim 18, wherein the LDI-Adenosine monomer has the formula: ### Claim 21 (depends on 16) The medical device of claim 16, wherein the Adenosine-LDI-Cysteine monomer has the formula: wherein R3 has the formula: and wherein each R is independently a unit having the formula: