# US 8,771,257 B2 · Drug delivery sheath

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- Number: US 8,771,257 B2
- Document ID: US8771257B2
- Status: Granted
- Kind: B2
- Application number: 10/964,890
- Filed: 2004-10-15
- Published: 2006-04-20
- Granted: 2014-07-08
- Earliest claimed: 2004-10-15
- Assignees: Boston Scientific Scimed, Inc.
- Applicants: David Hoffman
- Inventors: David Hoffman
- Web page: https://patentgrep.com/patent/US8771257B2

## CPC

- A61M 25/0068: {Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure}
- A61M 25/0071: {Multiple separate lumens (multiple separate lumens throughout the catheter A61M25/0026)}
- A61M 25/0075: {Valve means}
- A61M 2025/0057: {Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings}
- A61M 2025/091: {having a lumen for drug delivery or suction}
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

A cannulated drug delivery sheath having an annular wall and having a channel located within and extending partially through the annular wall. The annular wall defines a first lateral recess and a second lateral recess that are configured to respectively seat first and second cassettes containing therapeutic agents. The first and second lateral recesses have at least one first inlet port and at least one second inlet port, respectively. Also within the annular wall of the sheath is a first and second manifold. The first manifold is in fluid communication with the channel at one end and in fluid communication with the at least one first inlet port at another end. Similarly, the second manifold is in fluid communication with the channel at one end and in fluid communication with the at least one second inlet port at another end.

## Claims

### Claim 1

A drug delivery system comprising:
a sheath comprising:
an annular wall defining a cannula having at least one channel extending partially therethrough;
at least one lateral recess comprising:
a first lateral recess defined by the annular wall and seating a first rupturable cassette containing therapeutic agents, the first lateral recess having at least one first inlet port;
a second lateral recess defined by the annular wall and seating a second rupturable cassette containing therapeutic agents, the second lateral recess having at least one second inlet port; and
at least one manifold comprising:
a first manifold in fluid communication with the at least one channel and in fluid communication with the at least one first inlet port; and
a second manifold in fluid communication with the at least one channel and in fluid communication with the at least one second inlet port; and
a pressurized gas source comprising:
an actuator valve; and
a conduit connecting the pressurized gas source to the at least one channel of the sheath;
wherein, prior to an introduction of pressurized gas into the at least one channel, the first rupturable cassette contains therapeutic agents and the second rupturable cassette contains therapeutic agents.

### Claim 2 (depends on 1)

The drug delivery system of claim 1, wherein the at least one first inlet port comprises a plurality of first inlet ports.

### Claim 3 (depends on 2)

The drug delivery system of claim 2, wherein the first manifold comprises a plurality of first sub-channels, each of the plurality of first sub-channels in fluid communication with a respective one of the plurality of first inlet ports.

### Claim 4 (depends on 1)

The drug delivery system of claim 1, wherein the at least one second inlet port comprises a plurality of second inlet ports.

### Claim 5 (depends on 4)

The drug delivery system of claim 4, wherein the second manifold comprises a plurality of second sub-channels, each of the plurality of second sub-channels in fluid communication with a respective one of the plurality of second inlet ports.

### Claim 6 (depends on 1)

The sheath of claim 1 wherein the at least one lateral recess further comprises:
a third lateral recess defined by the annular wall and configured to seat a third rupturable cassette containing therapeutic agents, the third lateral recess having at least one third inlet port;
a fourth lateral recess defined by the annular wall and configured to seat a fourth rupturable cassette containing therapeutic agents, the fourth lateral recess having at least one fourth inlet port; and
wherein the at least one manifold further comprises:
a third manifold in fluid communication with the at least one channel and in fluid communication with the at least one third inlet port; and
a fourth manifold in fluid communication with the at least one channel and in fluid communication with the at least one fourth inlet port; and
further comprising:
a third rupturable cassette configured to be seated in the third lateral recess; and
a fourth rupturable cassette configured to be seated in the fourth lateral recess.

### Claim 7 (depends on 6)

The sheath of claim 6, wherein the third and fourth rupturable cassettes contain therapeutic agents.

### Claim 8 (depends on 1)

The drug delivery system of claim 1, wherein the therapeutic agents contained within the first rupturable cassette and the second rupturable cassette are engineered cells.

### Claim 9 (depends on 1)

The drug delivery system of claim 1, wherein therapeutic agents contained within each of the first rupturable cassette and the second rupturable cassette are a combination of engineered cells, antibiotics, and anesthetic agents.

### Claim 10 (depends on 1)

The drug delivery system of claim 1, wherein the therapeutic agents contained within the first rupturable and second rupturable cassettes are microencapsulated.

### Claim 11 (depends on 1)

A drug delivery system comprising:
the sheath of claim 1; and
an endoscope disposed within the cannula of the sheath of claim 1, the endoscope comprising a shaft having a proximal end, a distal end and a working channel extending therethrough.

### Claim 12 (depends on 11)

The drug delivery system of claim 11, wherein the distal end of the endoscope comprises a light source.

### Claim 13 (depends on 11)

The drug delivery system of claim 11, wherein the distal end of the endoscope comprises a vision chip.

### Claim 14 (depends on 11)

The drug delivery system of claim 11, further comprising:
a pressurized gas source comprising an actuator valve; and
a conduit connected to the pressurized gas source at one end and in fluid communication with the working channel of the endoscope at another end, the working channel in fluid communication with the at least one channel of the sheath.

### Claim 15 (depends on 14)

The drug delivery system of claim 14, wherein the pressurized gas is sterilized air.

### Claim 16 (depends on 1)

The sheath of claim 1, wherein the at least one channel comprises a first channel and a second channel, and wherein the first manifold is in fluid communication with the first channel and the second manifold is in fluid communication with the second channel.