# US 8,771,256 B2 · Device delivering medicines by transpalpebral electrophoresis

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 8,771,256 B2
- Document ID: US8771256B2
- Status: Granted
- Kind: B2
- Application number: 12/913,065
- Filed: 2010-10-27
- Published: 2011-04-28
- Granted: 2014-07-08
- Earliest claimed: 2001-10-12
- Assignees: Eyegate Pharma S.A.S.
- Applicants: Francine Behar-Cohen; Pierre Roy
- Inventors: Francine Behar-Cohen; Pierre Roy
- Web page: https://patentgrep.com/patent/US8771256B2

## CPC

- A61F 9/0017: {implantable in, or in contact with, the eye, e.g. ocular inserts}
- A61N 1/0436: {Material of the electrode}
- A61N 1/044: {Shape of the electrode}
- A61N 1/0448: {Drug reservoir}
- A61N 1/325: {for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body (electrodes for external use A61N1/0428)}
- A61N 1/0412: {Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs}
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

The invention concerns a device for ocular application of an active principle (1) comprising a main electrode (2) including an insulating layer, an adhesive layer designed to bind the insulating layer to a conductive layer, characterized in that the main electrode comprises a zone (21, 22) designed to be urged into contact with an eyelid.

## Claims

### Claim 1

A method for ocular application of an active substance through iontophoresis, the method comprising:
disposing a main electrode on an eyelid of a patient;
disposing a return electrode on a tissue of the patient away from the eyelid;
disposing an insert between the eyelid and the eyeball, the insert comprising the active substance and being disposed between the main electrode and the eyeball; and
substantially closing the eyelid and applying an electrical current circulating between the main electrode and the return electrode thereby allowing the active substance to penetrate the sclera of an eyeball of the patient via the applied electrical current, wherein the active substance penetrates into the eyeball via iontophoresis.

### Claim 2 (depends on 1)

A method according to claim 1, wherein the electrical current is a direct current (DC) having an amplitude between about 0.5 mA and about 10 mA.

### Claim 3 (depends on 1)

A method according to claim 1, further comprising impregnating an absorbent foam layer within the main electrode with the active substance.