# US 8,771,215 B2 · Machine for extracorporeal treatment of blood

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- Number: US 8,771,215 B2
- Document ID: US8771215B2
- Status: Granted
- Kind: B2
- Application number: 13/331,728
- Filed: 2011-12-20
- Published: 2012-04-19
- Granted: 2014-07-08
- Earliest claimed: 2004-07-23
- Assignees: Cambro Lundia AB
- Applicants: Claudio Tonelli; Bernd Wittner; Werner Beck; Helmut Hildwein; Reinhold Deppisch; Jonas Svensson; Bjorn Ericson
- Inventors: Claudio Tonelli; Bernd Wittner; Werner Beck; Helmut Hildwein; Reinhold Deppisch; Jonas Svensson; Bjorn Ericson
- Web page: https://patentgrep.com/patent/US8771215B2

## CPC

- A61M 1/16: with membranes
- A61M 1/1613: {Profiling or modelling of patient or predicted treatment evolution or outcome}
- A61M 1/1615: {using measurements made at different flow rates}
- A61M 1/1647: {with flow rate measurement of the dialysis fluid, upstream and downstream of the dialyser}
- A61M 1/341: {by measuring the filtrate rate or volume}
- A61M 1/3431: {upstream of the filter}
- A61M 1/3434: {with pre-dilution and post-dilution}
- A61M 1/3437: {downstream of the filter, e.g. post-dilution with filtrate}
- A61M 1/3465: {using dialysate as substitution fluid}
- A61M 1/3441: {Substitution rate control as a function of the ultrafiltration rate}
- A61M 1/3639: {Blood pressure control, pressure transducers specially adapted therefor}
- A61M 2205/52: with memories providing a history of measured variating parameters of apparatus or patient
- A61M 2205/60: with identification means
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

A machine (1) for extracorporeal blood treatment comprises a device (2) for ultrafiltration of a liquid through a semi-permeable membrane (3) of a blood treatment device (4), a first sensor (11) for ultrafiltration rate through the membrane, a second group of sensors (13) for measuring a trans-membrane pressure, an infusion line (16) with an infusion pump (17) and a programmed controller (14) for calculating a maximum infusion rate as a function of the transmembrane pressure. The machine is suitable for kidney failure treatments, such as hemofiltration and hemodiafiltration. In a relatively short time the machine enables a large quantity of corporeal blood to be removed from the patient.

## Claims

### Claim 1

A machine for extracorporeal blood treatment, comprising:
a blood treatment device having a blood chamber and a fluid chamber, separated one from another by the semipermeable membrane,
an extracorporeal blood circuit which comprises an arterial line, for taking blood removed from a patient to an inlet of the blood chamber, and a venous line, for returning treated blood from an outlet of the blood chamber to the patient,
a device for ultrafiltration of a liquid through the semipermeable membrane of the blood treatment device,
an infusion line connected to the extracorporeal blood circuit and provided with an infusion actuator for injecting into the extracorporeal blood an infusion flow of substitution liquid,
a controller configured to perform the following operations:
changing a transmembrane pressure across the semipermeable membrane of the blood treatment device;
detecting a plurality of values of an infusion flow rate through said infusion line on changing said transmembrane pressure; and
evaluating an optimal value of said infusion flow rate from a comparison of said plurality of values, the optimal value comprising at least one of equal to, and proximal to a maximum value of infusion flow rate through said infusion line as a function of said transmembrane pressure.

### Claim 2 (depends on 1)

The machine of claim 1, wherein said controller is configured to receive a set value for a patient weight loss rate and to control the ultrafiltration flow rate of liquid through the semipermeable membrane and the infusion flow rate such that the ultrafiltration flow rate is equal to the sum of the patient weight loss flow rate and infusion flow rate.

### Claim 3 (depends on 1)

The machine of claim 1, wherein said controller is configured to receive a set value for a patient weight loss rate and to calculate an optimal value for an ultrafiltration flow rate of liquid through the semipermeable membrane based on said evaluated optimal value of the infusion flow rate and on the set value for the patient weight loss rate.

### Claim 4 (depends on 2)

The machine of claim 2, wherein said controller is configured to calculate an optimal value for an ultrafiltration flow rate of liquid through the semipermeable membrane based on said evaluated optimal value of the infusion flow rate and on the set value for the patient weight loss rate.

### Claim 5 (depends on 3)

The machine of claim 3, wherein the controller is configured to perform the operation of selecting an optimal operating situation of said ultrafiltration device from said optimal value for the ultrafiltration flow rate.

### Claim 6 (depends on 3)

The machine of claim 3, wherein said controller is configured to perform the operation of setting said ultrafiltration device on said optimal operating situation.

### Claim 7 (depends on 1)

The machine of claim 1, wherein said optimal value of the infusion flow rate comprises the maximum value of infusion flow rate through said infusion line as a function of a transmembrane pressure.

### Claim 8 (depends on 7)

The machine of claim 7, wherein said controller is configured to perform an operation of setting the transmembrane pressure as a function of the transmembrane pressure corresponding to said maximum of infusion flow rate.

### Claim 9 (depends on 8)

The machine of claim 8, wherein the controller is configured to set the transmembrane pressure to a value corresponding to said maximum of infusion flow rate lowered by a predetermined percentage or by a predetermined amount if said transmembrane pressure is within a predetermined range.

### Claim 10 (depends on 1)

The machine of claim 1, wherein before said operation of changing the transmembrane pressure across the semipermeable membrane, said controller is configured to perform the operation of imposing a volume control mode for a predetermined time period with an infusion rate of substitution liquid determined as a set value or as a function of the blood flow rate.

### Claim 11 (depends on 1)

The machine of claim 1, wherein:
said ultrafiltration device comprises at least one fluid circulation pump which operates on a line of ultrafiltered liquid; and
said operation of changing the transmembrane pressure across the semipermeable membrane comprises a changing of the speed of rotation of the fluid circulation pump.

### Claim 12 (depends on 1)

The machine of claim 1, comprising at least a sensor for measuring an ultrafiltration flow rate of liquid through said membrane, at least a sensor for measuring the infusion flow rate through the infusion line and at least a sensor for measuring the transmembrane pressure.

### Claim 13 (depends on 1)

The machine of claim 1, wherein said operation of evaluating an optimal value of infusion flow rate comprises phases of:
determining at least one change in infusion flow rate caused by said change in transmembrane pressure across the semipermeable membrane;
checking whether said change in infusion flow rate and said change transmembrane pressure across the semipermeable membrane agree with a predetermined relation with a reference value;
generating a signal consequent to said checking phase.

### Claim 14 (depends on 13)

The machine of claim 13, wherein said predetermined relation comprises a quotient between said change ultrafiltration flow rate and said change in transmembrane pressure across the semipermeable membrane.

### Claim 15 (depends on 14)

The machine of claim 14, wherein said predetermined relation is satisfied if said quotient is less than a reference value.

### Claim 16 (depends on 14)

The machine of claim 14, wherein said controller is configured to repeat said phases if said relation is not satisfied.

### Claim 17 (depends on 1)

The machine of claim 1, wherein said controller is configured to periodically repeat said operations.

### Claim 18

A machine for extracorporeal treatment of blood, comprising:
a blood treatment device having a blood chamber and a fluid chamber, separated one from another by the semipermeable membrane;
an extracorporeal blood circuit which comprises an arterial line, for taking blood removed from a patient to an inlet of the blood chamber, and a venous line, for returning treated blood from an outlet of the blood chamber to the patient;
an infusion line connected to the extracorporeal blood circuit and provided with an infusion pump for injecting into the extracorporeal blood an infusion flow of substitution liquid;
at least an ultrafiltration pump connected to said fluid chamber and configured for ultrafiltration of a liquid through the semipermeable membrane of the blood treatment device;
at least a blood pump for supplying a flow of liquid to the blood chamber of said blood treatment device;
at least a first sensor configured for measuring an ultrafiltration flow rate through said semipermeable membrane;
at least a second sensor configured for measuring an infusion flow rate through said infusion line;
at least a third sensor for measuring a transmembrane pressure across said semipermeable membrane;
a controller configured for performing the following operations:
determining at least one value of an infusion flow rate and at least one value of a transmembrane pressure in a first operating situation of said ultrafiltration pump;
commanding said ultrafiltration pump to change into a second operating situation which is different from the first operating situation thereof;
determining at least one value of an infusion flow rate and at least one value of a transmembrane pressure in said second operating situation;
checking whether said values related to two different operating situations satisfy a predetermined relation with a reference value;
generating a signal in consequence of said check;
depending upon the outcome of said check repeating or not the above-described operations; and
finding a maximum or nearly-maximum value for the infusion flow rate as a function of the transmembrane pressure.

### Claim 19 (depends on 18)

The machine of claim 18, wherein said controller is configured to receive a set value for a patient weight loss rate and to control the ultrafiltration flow rate of liquid through the semipermeable membrane and the infusion flow rate such that the ultrafiltration flow rate is equal to the sum of the patient weight loss flow rate and infusion flow rate.

### Claim 20 (depends on 18)

The machine of claim 18, wherein the controller is configured to set the ultrafiltration pump at an optimal operating situation corresponding to the maximum or nearly-maximum value for the infusion flow rate as a function of the transmembrane pressure.

### Claim 21 (depends on 18)

The machine of claim 18, wherein said predetermined relation comprises a quotient between said change in infusion flow rate and said change in transmembrane pressure across the semipermeable membrane, and wherein said predetermined relation is satisfied if said quotient is less than a reference value.