# US 8,771,194 B2 · Modulation and analysis of cerebral perfusion in epilepsy and other neurological disorders > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,771,194 B2 - Document ID: US8771194B2 - Status: Granted - Kind: B2 - Application number: 13/714,387 - Filed: 2012-12-13 - Published: 2013-04-25 - Granted: 2014-07-08 - Earliest claimed: 2004-12-15 - Assignees: NeuroPace, Inc. - Applicants: NeuroPace, Inc. - Inventors: Michael S. John; Benjamin D. Pless; Brett M. Wingeier - Web page: https://patentgrep.com/patent/US8771194B2 ## CPC - A61N 1/36139: {with automatic adjustment} - A61B 5/02: Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow - A61B 5/14553: {specially adapted for cerebral tissue} - A61B 5/37: Intracranial electroencephalography [IC-EEG], e.g. electrocorticography [ECoG] - A61B 5/372: Analysis of electroencephalograms - A61B 5/4094: {Diagnosing or monitoring seizure diseases, e.g. epilepsy} - A61F 7/00: Heating or cooling appliances for medical or therapeutic treatment of the human body (hyperthermia using electric or magnetic fields or ultrasound A61N) - A61F 7/12: Devices for heating or cooling internal body cavities - A61N 1/36057: {adapted for stimulating afferent nerves} - A61N 1/36064: {Epilepsy} - A61N 1/3614: {based on impedance measurement} - A61N 2/006: {for magnetic stimulation of nerve tissue} - A61N 7/00: Ultrasound therapy (lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 {; using ultrasound for introducing media into the body A61M37/0092}) - A61B 5/0031: {Implanted circuitry} - A61B 5/1459: invasive, e.g. introduced into the body by a catheter - A61B 5/6868: {Brain} - A61B 5/7217: {of noise originating from a therapeutic or surgical apparatus, e.g. from a pacemaker} - A61B 8/06: Measuring blood flow - A61B 8/12: in body cavities or body tracts, e.g. by using catheters - A61B 8/488: {involving Doppler signals} - A61N 1/36082: {Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease} - A61N 2/02: using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence) - A61N 5/0622: {Optical stimulation for exciting neural tissue} - A61N 2007/0043: {intra-cavitary} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) ## Abstract A system including an implantable neurostimulator device capable of modulating cerebral blood flow to treat epilepsy and other neurological disorders. In one embodiment, the system is capable of modulating cerebral blood flow (also referred to as cerebral perfusion) in response to measurements and other observed conditions. Perfusion may be increased or decreased by systems and methods according to the invention as clinically required. ## Claims ### Claim 1 A method for responding to a neurological disorder in a human patient comprising: generating, by an implantable device, a signal representative of a cerebral perfusion measurement; receiving and processing, by the implantable device, at predetermined times, a cerebral perfusion measurement; automatically identifying, by the implantable device, a condition in the signal, wherein the condition comprises a predetermined change in cerebral perfusion; identifying, by the implantable device, a structure in a first hemisphere, monitoring, by the implantable device, the first hemisphere for increased blood flow; and automatically performing an action, by the implantable device, wherein the action comprises generating an instruction for therapy based on the identified change in the cerebral perfusion, wherein the therapy comprises stimulating a neural structure in a second hemisphere that is contralateral to the first hemisphere. ### Claim 2 (depends on 1) The method of claim 1, wherein the therapy is intended to return the cerebral perfusion measurement to a desired value or range of values. ### Claim 3 (depends on 1) The method of claim 1, further comprising: continuously monitoring the signal; and identifying, with an algorithm, a predetermined change in the cerebral perfusion, wherein the algorithm uses at least one of a control law or a threshold comparison to determine whether to cause an instruction to provide responsive therapy. ### Claim 4 (depends on 1) The method of claim 1, wherein the therapy is adapted to modulate the cerebral perfusion by modulating at least one of electrical activity or chemical activity in the brain. ### Claim 5 (depends on 1) The method of claim 1, further comprising: acquiring an oximetry measurement. ### Claim 6 (depends on 5) The method of claim 5, further comprising: delivering optical stimulation as a therapy in response to the identified condition and upon receiving an optical stimulation delivery instruction. ### Claim 7 (depends on 1) The method of claim 1, further comprising: acquiring an electromagnetic field measurement. ### Claim 8 (depends on 7) The method of claim 7, further comprising: delivering electromagnetic stimulation as a therapy in response to the identified condition and upon receiving an electromagnetic stimulation delivery instruction. ### Claim 9 (depends on 1) The method of claim 1, further comprising: acquiring a temperature measurement. ### Claim 10 (depends on 9) The method of claim 9, further comprising: delivering thermal stimulation as a therapy to cool or heat a region of the patient's brain in response to the identified condition and upon receiving a thermal stimulation delivery instruction. ### Claim 11 (depends on 1) The method of claim 1, further comprising: delivering ultrasonic wave to a region of the patient's brain through a component adapted to deliver ultrasonic waves. ### Claim 12 (depends on 1) The method of claim 1, further comprising: acquiring a measurement of oxygen concentration. ### Claim 13 (depends on 1) The method of claim 1, further comprising: measuring, by an electrode, electrical impedance. ### Claim 14 (depends on 1) The method of claim 1, further comprising: measuring an electro graphic signal. ### Claim 15 (depends on 1) The method of claim 1, further comprising: delivering electrical stimulation through a stimulation electrode. ### Claim 16 (depends on 1) The method of claim 1, wherein the condition further comprises: a representation of cortical depression. ### Claim 17 (depends on 1) The method of claim 1, wherein the condition further comprises: a representation of oxygen availability.