# US 8,771,176 B2 · Capsule camera with variable illumination of the surrounding tissue

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- Number: US 8,771,176 B2
- Document ID: US8771176B2
- Status: Granted
- Kind: B2
- Application number: 12/374,506
- Filed: 2007-04-12
- Published: 2009-07-09
- Granted: 2014-07-08
- Earliest claimed: 2006-07-24
- Assignees: Koninklijke Philips N.V.
- Applicants: Bernardus Hendrikus Wilhelmus Hendriks; Michael Harald Kuhn; Thomas Zaengel; Nijs Cornelis Van Der Vaart
- Inventors: Bernardus Hendrikus Wilhelmus Hendriks; Michael Harald Kuhn; Thomas Zaengel; Nijs Cornelis Van Der Vaart
- Web page: https://patentgrep.com/patent/US8771176B2

## CPC

- A61B 1/0627: {for variable illumination angles}
- A61B 1/00087: {Tools (A61B17/00234 takes precedence)}
- A61B 1/00188: {with focusing or zooming features}
- A61B 1/0019: {characterised by variable lenses}
- A61B 1/041: {Capsule endoscopes for imaging}
- A61B 1/042: {characterised by a proximal camera, e.g. a CCD camera}
- A61B 1/043: {for fluorescence imaging}
- A61B 1/0625: {for multiple fixed illumination angles}
- A61B 5/0066: {Optical coherence imaging}
- A61B 5/0071: {by measuring fluorescence emission}
- A61B 18/20: using laser
- G03B 15/02: Illuminating scene
- A61B 1/00165: {with light-conductive means, e.g. fibre optics (A61B1/07 takes precedence)}
- A61B 5/0084: {for introduction into the body, e.g. by catheters (A61B5/1459 takes precedence)}
- A61B 2018/00482: {Digestive system}
- A61B 2018/00577: {Ablation}
- A61B 2018/00589: {Coagulation}
- A61B 2018/00642: {with feedback, i.e. closed loop control}
- A61B 2018/00904: {Automatic detection of target tissue}
- A61N 5/0601: {Apparatus for use inside the body}
- A61N 5/0603: {for treatment of body cavities}
- A61N 5/062: {Photodynamic therapy, i.e. excitation of an agent}
- A61N 2005/0609: {Stomach and/or esophagus}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G03B: APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR (optical parts of such apparatus G02B; photosensitive materials or processes for photographic purposes G03C; apparatus for processing exposed photographic materials G03D)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

The application relates to an ingestible capsule and method for in vivo imaging and/or treatment of one or more diseased areas of interest within the gastrointestinal tract of an animal or human being. The capsule comprises an image sensor; a lens system for focusing images onto the image sensor; at least one light source for illumination of the tissue area of interest, the at least one light source optionally being capable of providing optical therapeutic treatment to the diseased areas; a variable lens system located in front of the at least one light source, wherein the variable lens system comprises beam steering means and focusing means for directing and focusing the light beams from the at least one light source onto the diseased tissue areas, —a control unit in communication with the image sensor, the at least one light source, and variable lens system, a power source for powering the image sensor, the at least one light source and the control unit; and a non-digestible, transparent outer protective shell configured to pass through the gastrointestinal tract, housing within the image sensor, the lens system, the at least one light source, the variable lens system, the control unit and the power source.

## Claims

### Claim 1

An ingestible untethered capsule for in vivo imaging and/or treatment of diseased tissue within a gastrointestinal tract of an animal or human being, said capsule comprising:
a camera including an image sensor and a first lens located in front of the image sensor for taking images of the diseased tissue;
at least one light source located laterally adjacent the image sensor for providing one or more light beams for illumination and optical therapeutic treatment of the diseased tissue;
a second lens located in front of the at least one light source for focusing at least one of the light beams from the at least one light source on a focus spot along a first path in a first direction onto the diseased tissue; and
a controller connected to the camera and the second lens and configured to correct for motion of the capsule by controlling the second lens to maintain the focus spot as the capsule moves within the gastrointestinal tract.

### Claim 2 (depends on 1)

The ingestible capsule of claim 1, wherein the at least one light source includes first and second light source, the second light source providing optical therapeutic treatment to the diseased tissue.

### Claim 3 (depends on 2)

The capsule of claim 2, wherein the first and second light sources comprise lasers.

### Claim 4 (depends on 1)

The capsule of claim 1, wherein the second lens comprises a liquid lens system.

### Claim 5 (depends on 1)

The capsule of claim 1, further comprising an outer protective shell, wherein the outer protective shell is non-digestible, transparent, and configured to pass through the gastrointestinal tract.

### Claim 6 (depends on 1)

The capsule of claim 1, further comprising a power source for powering the image sensor, the at least one light source and the control unit.

### Claim 7 (depends on 1)

The capsule of claim 1, wherein the controller further comprising a memory for storing images received from the image sensor as the capsule travels through the gastrointestinal tract and a transmitter for transfer the stored images, the controller is configured to control the at least one light source and the second lens and to correlate and transfer the stored images.

### Claim 8 (depends on 1)

The capsule of claim 1, wherein the power source is externally driven with a magnetic signal to produce electrical power to enable continuous imaging and treatment of the diseased tissue.

### Claim 9 (depends on 1)

The capsule of claim 1, further comprising
a detector located in front of the at least one light source configured to detect second light beams reflected from the diseased tissue in a second direction opposite the first direction along the first path; and
a beam splitter configured to focus the light beams and the reflected second light beams on the detector through an aperture,
wherein to correct for motion of the capsule the controller correlates successive images of the focus spot and keeps the focus spot on the tissue area to be treated by changing settings of the second lens that is scanning the reflected light beams.

### Claim 10

An ingestible untethered capsule for in vivo imaging and/or treatment diseased tissue within a gastrointestinal tract of animal or human being, said capsule comprising:
a camera including an image senor and first lens located in front of the image sensor for taking in images of the diseased tissue;
at least one light source located laterally adjacent the camera for providing one or more light beams for illumination and optical therapeutic treatment of the diseased tissue;
a second lens located in front of the at least one light source for focusing at least one of the light beams from the at least one light source on a focus spot along a first path in a first direction onto the diseased tissue; and
a detector located in front of the at least one light source for detecting second light beams reflected from the diseased tissue in a second direction opposite the first direction along the first path;
a beam splitter located in front of the detector and configured to focus the light beams and the reflected second light beams on the detector through an aperture; and
a controller connected to the camera, the second lens, and the beam splitter and configured to correct for motion of the capsule by changing settings of the second lens to maintain the focus spot, after reconstructing the images of the diseased tissue,
wherein the second lens is scanning the reflected light beams.