# US 8,770,046 B2 · Autosampler with control unit for performing a cleaning operation

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- Number: US 8,770,046 B2
- Document ID: US8770046B2
- Status: Granted
- Kind: B2
- Application number: 13/382,499
- Filed: 2010-09-01
- Published: 2012-05-10
- Granted: 2014-07-08
- Earliest claimed: 2009-09-07
- Assignees: Shimadzu Corporation
- Applicants: Yoshiaki Maeda; Kenichi Yasunagi; Takafumi Nakamura
- Inventors: Yoshiaki Maeda; Kenichi Yasunagi; Takafumi Nakamura
- Web page: https://patentgrep.com/patent/US8770046B2

## CPC

- G01N 30/24: Automatic injection systems
- G01N 30/20: using a sampling valve
- G01N 35/1097: {characterised by the valves (valves in general F16K)}
- G01N 30/18: using a septum or microsyringe
- G01N 2030/202: {rotary valves}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

An autosampler is provided with a needle, a measuring pump which sucks and discharges liquid through the needle, a movement mechanism for the needle, and an injection port which has a needle sealing surface. A sample liquid is sucked into the needle and then the sample liquid discharged with the tip of the needle pressed to the needle sealing surface. When cleaning the needle sealing surface, a cleaning liquid within the injection port is sucked and then the cleaning liquid is discharged and sucked into the injection port at a position at which the tip of the needle does not make contact with the needle sealing surface. Alternatively, after the cleaning liquid is discharged into the injection port, the needle may be caused to perform an up and down motion such that the tip of the needle contacts the needle sealing surface and then is lifted.

## Claims

### Claim 1

An autosampler comprising:
a needle whose tip is formed to be tapered;
a measuring-pump for discharging and drawing in by suction a liquid through said needle;
a movement mechanism for moving said needle in a horizontal direction and a vertical direction;
an injection port having a needle-sealing surface and connected to an analysis flow path via a valve; and
a control unit for controlling said measuring-pump and said movement mechanism,
wherein after a sample solution that is held in a sample vessel is drawn in by suction through said needle, the tip of said needle is pressed against said needle-sealing surface and said sample solution is discharged so that said sample solution is introduced into said analysis flow path through said injection port; and
said control unit performs a cleaning operation for cleaning said needle-sealing surface by causing said measuring-pump to draw in from a cleaning liquid vessel by suction, an amount of a cleaning liquid to be held within said injection port, then causing said needle to be moved to a position where the tip of said needle does not contact said needle-sealing surface and then causing said measuring-pump to cause a discharge and suction of the cleaning liquid into and from said injection port through said needle.

### Claim 2 (depends on 1)

The autosampler according to claim 1 wherein said control unit causes said cleaning operation to be performed a plurality of times.

### Claim 3 (depends on 1, 2)

The autosampler according to claim 1 or 2 wherein said needle is lowered when a cleaning operation is performed by said control unit.

### Claim 4 (depends on 3)

The autosampler according to claim 3 wherein, when said control unit performs a cleaning operation, an up-and-down motion of the needle involving lowering said needle to a position where the tip of said needle comes into contact with said needle-sealing surface and then raising said needle to a position where the tip of the needle is not in contact with said needle-sealing surface is performed once or a plurality of times during the time from the discharge of said cleaning liquid to the suction of said cleaning liquid by said measuring pump.

### Claim 5

An autosampler comprising:
a needle whose tip is formed to be tapered;
a measuring-pump for discharging and drawing in by suction a liquid through said needle;
a movement mechanism for moving said needle in a horizontal direction and a vertical direction;
an injection port having a needle-sealing surface and connected to an analysis flow path via a valve; and
a control unit for controlling said measuring-pump and said movement mechanism;
wherein after a sample solution that is held in a sample vessel is drawn in by suction through said needle, the tip of said needle is pressed against said needle-sealing surface and said sample solution is discharged so that said sample solution is introduced into said analysis flow path through said injection port; and
said control unit performs a cleaning operation for cleaning said needle-sealing surface by causing said measuring-pump to draw in from a cleaning liquid vessel by suction, an amount of a cleaning liquid to be held within said injection port, then causing said needle to be moved to a position where the tip of said needle does not contact said needle-sealing surface, then causing said measuring-pump to discharge said cleaning liquid, then raising said needle to a position where the tip of said needle is not in contact with the surface of the cleaning liquid that is held within said injection port, and then causing said measuring-pump to draw air in by suction and then discharge the air.

### Claim 6 (depends on 1)

The autosampler according to claim 1 wherein said control unit cleans the interior of an analysis flow path by causing the tip of said needle to be pressed against said needle-sealing surface and causing said measuring-pump to discharge into and draw in by suction said cleaning liquid from said injection port through said needle.