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US 8,768,629 B2Granted
Molecular profiling of tumors
AssigneeCaris MPI, Inc.
InventorsDaniel D. Von Hoff, Alan Wright, Matthew J. McGinniss, Ryan P. Bender, David M. Loesch, Arlet Alarcon, Robert J. Penny, Traci Pawlowski
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Abstract
Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.
Claims48
A method of identifying one or more candidate treatment for a subject in need of treatment for a cancer, comprising:
- (a) performing an immunohistochemistry (IHC) analysis on a sample from the subject on at least:
- TOP1, TYMS, MGMT, PTEN, ERBB2, and SPARC;
- (b) performing a microarray analysis on the sample on at least:
- TOP1, TYMS, MGMT, PTEN, ERBB2, and SPARC;
- (c) performing a fluorescent in-situ hybridization (FISH) analysis on the sample on ERBB2;
- (d) performing DNA sequencing analysis on the sample on PIK3CA, KRAS, and BRAF;
- and
- (e) using a computer to access a rules database comprising the biomarker-drug association rules presented in Table 2 and perform all rules in the database for each gene or gene product analyzed in steps a)-d);
- and
- (f) producing a computer generated report based on the rules s performed in step e), wherein the report identifies the one or more candidate treatment.
7 more elements
Dependencies are inferred from the claim text.