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US 8,765,147 B2Granted
Endophytic fungi from Pteromischum sp. plant, compounds and methods of use
AssigneeThe Regents of the University of California
InventorsGary A. Strobel, Yuhao Ren, David B. Teplow
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Abstract
The present disclosure relates to endophytic fungi from higher plants such as a Pteromischum sp. plant, and to extracts and compounds from such fungi that have desirable biological activities, such as antifungal and immunosuppressive activities. The present disclosure further relates to compositions comprising such extracts and compounds, as well as methods of making and using the compositions.
Claims7
A method of suppressing an immune response, comprising:
- administering to a subject in need of immunosuppression a therapeutically effective amount of a compound which is a peptide obtained from Colletotrichum dematium, wherein the peptide has a molecular mass of about 1127.7 Da and a tetrapeptide sequence Val-Ile-Ser-Ile (SEQ ID NO:1) thereby suppressing the immune response.
Dependencies are inferred from the claim text.