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US 8,759,306 B2Granted
RNAi for the control of insects and arachnids
AssigneeDevgen NV
InventorTitus Jan Kaletta
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AssigneeDevgen NV
InventorTitus Jan Kaletta
Estimating the term…
The present invention describes a new non-compound based approach for insect and/or arachnid control. The present inventors have identified for the first time novel targets for RNAi, which can effectively control insect and/or arachnid pest populations. Accordingly, the invention provides both nucleotide and amino acid sequences for the novel targets. Also provided are RNA constructs including double stranded RNA regions for mediating RNAi in insects, DNA constructs, expression vectors, host cells and compositions for controlling insects and/or arachnids using RNAi. Finally, the invention also provides for the use of the constructs, vectors, host cells and compositions in control of insects and/or arachnids populations and suitable kits for use in an RNAi based method of controlling insect and/or arachnid pests.
An RNA construct comprising at least one double stranded RNA region, at least one strand of which comprises a nucleotide sequence that is complementary to at least 24 nucleotides of a nucleotide sequence as set forth in any one of SEQ ID NOs:
A method for controlling cockroach pests comprising providing to the cockroach an RNA construct comprising at least one double stranded RNA region, at least one strand of which comprises a nucleotide sequence that is complementary to at least 21 nucleotides of a nucleotide sequence as set forth in any of SEQ ID NOs 1, 6, 9, 10, 65-70, 73 to 76 and 78, or the complement thereof.
An RNA construct comprising at least one double stranded RNA region, at least one strand of which comprises at least 24 nucleotides or more of any of the nucleic acid molecules comprising the nucleotide sequence as set forth in any of SEQ ID NOs 1, 6, 9, 10, 65 to 70, 73 to 76 and 78, or the complement thereof.
Dependencies are inferred from the claim text.