Cationic lipids
AssigneeThe University Court of the University of Edinburgh
InventorsAsier Unciti-Broceta, Aleksandra Liberska, Mark Bradley
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Abstract
The invention provides a cationic lipid comprising: (i) one head group, comprising one or more amino acids, in which at least one amino acid has a side chain that comprises a cationic moiety or a cationic precursor; (ii) a linking moiety of formula (5): —(HNR5)2NC(O)R3C(O)— (5), wherein: each R5 is independently an optionally substituted C1-4 alkylene moiety; and R3 is an optionally substituted alkylene or alkenylene moiety; and (iii) two lipophilic moieties, wherein the head group and each of the lipophilic moieties are connected to the linking moiety through amide linkages.
Claims20
A cationic lipid of formula (10):
- wherein:
- each R1 is independently hydrogen or a C1-5 alkyl;
- n is from 1 to 10;
- each R2 is independently the side chain of an α-amino acid, at least one R2 group comprising a cationic moiety or a cationic precursor;
- each R5 is independently an optionally substituted C1-4 alkylene moiety;
- R3 is an optionally substituted alkylene or alkenylene moiety;
- and
- R6 represents a saturated or unsaturated fatty alkyl chain, optionally comprising fused cyclic regions whereby to form a polycyclic hydrocarbyl moiety.
Dependencies are inferred from the claim text.