DLIN-KC2-DMA lipid nanoparticle delivery of modified polynucleotides
AssigneeModerna Therapeutics, Inc.
InventorsAntonin de Fougerolles, Kristy M. Wood, Sayda M. Elbashir, Jason P. Schrum
Life of this patent
Estimating the term…
Abstract
The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
Claims7
A method for producing a protein of interest in a mammal comprising contacting said mammal with a modified mRNA comprising SEQ ID NO:
- 10 formulated in a lipid nanoparticle.
Dependencies are inferred from the claim text.