Fibrin foam and process
AssigneesBaxter International Inc., Baxter Healthcare S.A.
InventorYves A. Delmotte
Life of this patent
Estimating the term…
Abstract
A fibrin wound dressing is made by mixing quantities of fibrinogen solution and thrombin solution with air. The resulting foam is very light weight, and with the proper attention to the amount of thrombin, is also sufficiently viscous to rest on a vertical surface without dripping. The wound dressing may also be formulated for its ability to continue migration of healing substances, such as PDGF, from the dressing to the wound site. Thrombin substitutes, such as other clotting proteins, may be used instead of thrombin. The resulting foam may also be lyophilized or ground and lyophilized for later reconstitution. A therapeutic drug or other additive may also be added to the wound dressing.
Claims8
A method for forming a fibrin foam, the method comprising:
- combining a solution of fibrinogen with air by passing the fibrinogen and air through an inline mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough to form a first foam;
- combining a solution of a clotting protein with air by passing the clotting protein and air through an inline mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough to form a second foam;
- and
- mixing the first and second foams to form a fibrin foam, wherein the fibrin foam has a viscosity sufficient for a thin coating of the fibrin foam to adhere to a vertical surface.
Dependencies are inferred from the claim text.