Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, Alzheimer'S disease, sleep disorders, Parkinson'S disease, AIDS, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like

A programmable transdermal drug delivery device comprising:

• (a) an interface for coupling to the skin of a subject;
• (b) a reservoir storing a quantity of an active substance, carrier materials, or a combination thereof;
• (c) a delivery mechanism for modulating the quantity of the active substance supplied from the reservoir to the interface in response to a control signal;
• (d) an electronic programmable timing mechanism coupled to the delivery mechanism and configured to generate the control signal according to a programmed administration schedule;
• (e) a mechanism for removing the active substance and/or carrier materials from the interface, which functions to stop permeation or dosing of the active substance, while the device is maintained in contact with the skin of the subject;
• and
• (f) an actuator to provide for controlled stopping of the delivery of the active substance.

A programmable transdermal drug delivery device comprising:

• (a) an interface for coupling to the skin of a subject;
• (b) a reservoir storing a quantity of an active substance, carrier materials, or a combination thereof;
• (c) a delivery mechanism for modulating the quantity of the active substance supplied from the reservoir to the interface in response to a control signal;
• (d) an electronic programmable timing mechanism coupled to the delivery mechanism and configured to generate the control signal according to a programmed administration schedule;
• (e) a mechanism for removing the active substance and/or carrier materials from the interface, which functions to stop permeation or dosing of the active substance, while the device is maintained in contact with the skin of the subject;
• and
• (f) one or more micro-fabricated structures, wherein the micro-fabricated structure is micro-needles.