# US 8,739,727 B2 · Coated medical device and method for manufacturing the same

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- Number: US 8,739,727 B2
- Document ID: US8739727B2
- Status: Granted
- Kind: B2
- Application number: 13/646,916
- Filed: 2012-10-08
- Published: 2013-04-18
- Granted: 2014-06-03
- Earliest claimed: 2004-03-09
- Assignees: Boston Scientific Scimed, Inc.
- Applicants: Boston Scientific Scimed, Inc.
- Inventors: Michael Austin; Don Robinson; Dennis R. Boulais; Praveen Kulkarni; Toby Freyman; Samuel J. Epstein; Wendy Naimark; Marlene Schwarz
- Web page: https://patentgrep.com/patent/US8739727B2

## CPC

- B05C 1/0813: {characterised by means for supplying liquid or other fluent material to the roller}
- A61F 2/91: made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
- A61F 2/915: with bands having a meander structure, adjacent bands being connected to each other
- A61L 31/10: Macromolecular materials
- A61L 31/14: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- B05C 1/022: {to the outer surface of hollow articles (B05C1/027 takes precedence)}
- B05C 1/08: using a roller {or other rotating member which contacts the work along a generating line}
- B05C 1/0817: {characterised by means for removing partially liquid or other fluent material from the roller, e.g. scrapers (coating roller co-operating with dosing rollers B05C1/0834)}
- B05D 1/28: performed by transfer from the surfaces of elements carrying the liquid or other fluent material, e.g. brushes, pads, rollers
- A61F 2002/91533: {characterised by the phase between adjacent bands}
- A61F 2002/91558: {connected peak to peak}
- A61F 2250/0068: the pharmaceutical product being in a reservoir
- A61L 2300/606: Coatings
- A61L 2420/08: Coatings comprising two or more layers
- B05C 1/14: using a travelling band
- B05C: APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL (spraying apparatus, atomising apparatus, nozzles B05B; plant for applying liquids or other fluent materials to objects by electrostatic spraying B05B5/08)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- B05D: PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL (conveying articles or workpieces through baths of liquid B65G, e.g. B65G49/02)

## Abstract

The medical device of the invention comprises a surface comprising at least one outermost portion and a plurality of depressions. The depressions occupy at least about 80% of the surface area of the surface. The depressions contain a coating material that preferably comprises a biologically active material and/or polymer, and the outermost portion is substantially free of any coating material. The invention is also directed to a method for manufacturing a medical device. The method comprises applying a coating material to the surface of the medical device by using at least one roller.

## Claims

### Claim 1

A system for coating a medical device having a tubular portion with an outer surface, wherein the system comprises:
a coating material source containing a coating material;
a first roller having a surface;
a second roller having a surface;
a third roller having a surface; and
a flexible webbing material position around the second and third rollers;
wherein the first roller is situated relative to the coating material source so that the coating material can be transferred to the first roller surface; the first roller and webbing are situated relative to each other so that the first roller can transfer the coating material transferred to the first roller surface to the webbing; and the webbing is situated relative to the tubular portion so that the webbing can transfer the coating material transferred to the webbing to the outer surface of the tubular portion.

### Claim 2 (depends on 1)

The system of claim 1, which further comprises a reservoir that continuously supplies the coating material source with coating material.

### Claim 3 (depends on 2)

The system of claim 2, wherein the reservoir is a fermentor containing cells.

### Claim 4 (depends on 1)

The system of claim 1, further comprising an energy source for converting the coating material applied to the outer surface of the tubular portion into a coating.

### Claim 5 (depends on 1)

The system of claim 1, wherein the coating material comprises a genetic material.

### Claim 6 (depends on 1)

The system of claim 1, wherein the coating material comprises an antibiotic or an antiproliferative agent.

### Claim 7 (depends on 1)

The system of claim 1, wherein the webbing contacts the outer surface of the tubular portion.

### Claim 8 (depends on 1)

The system of claim 1, further comprising a mechanism for removing excess coating material from the webbing.

### Claim 9 (depends on 1)

The system of claim 1, further comprising a metering mechanism arranged to control an amount of coating material carried by said webbing.

### Claim 10 (depends on 9)

The system of claim 9, said metering mechanism comprising a metering roller.

### Claim 11 (depends on 10)

The system of claim 10, further comprising a doctor blade arranged to remove coating material from said metering roller.

### Claim 12 (depends on 9)

The system of claim 9, wherein said metering mechanism is located adjacent said second roller.

### Claim 13 (depends on 9)

The system of claim 9, wherein a distance between said metering mechanism and said webbing is adjustable.

### Claim 14 (depends on 1)

The system of claim 1, wherein coating material is transferred from said webbing to said medical device at a location spaced away from said second and third rollers.

### Claim 15 (depends on 1)

The system of claim 1, further comprising a doctor blade.

### Claim 16 (depends on 1)

The system of claim 1, wherein said webbing forms a continuous loop that extends around the second and third rollers.
