Carbonate prodrugs and methods of using the same
AssigneeAcorda Therapeutics, Inc.
InventorsNaweed Muhammad, Keith R. Bley
Life of this patent
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Abstract
The present invention provides carbonate prodrugs which comprise a carbonic phosphoric anhydride prodrug moiety attached to the hydroxyl or carboxyl group of a parent drug moiety. The prodrugs may provide improved physicochemical properties over the parent drug. Also provided are methods of treating a disease or condition that is responsive to the parent drug using the carbonate prodrugs, as well as kits and unit dosages.
Claims11
A prodrug comprising:
- (a) a moiety of parent drug, wherein the parent drug comprises a hydroxyl group;
- and
- (b) a prodrug moiety of the formula:
- wherein the prodrug moiety is bound to the moiety of the parent drug at the hydroxyl group providing a carbonate moiety;
- or a pharmaceutically acceptable salt thereof or solvate of the foregoing.
A prodrug of the formula:
- or a pharmaceutically acceptable salt thereof or solvate of the foregoing.
A kit for the treatment or prevention of pain, fever, inflammation, ischemic injury, or neuronal injury, comprising a prodrug of the formula:
- or a pharmaceutically acceptable salt thereof or solvate of the foregoing;
- and instructions for use in the treatment or prevention of pain, fever, inflammation, ischemic injury, or neuronal injury.
Dependencies are inferred from the claim text.