Methods and systems for chemical ablation

A chemical ablation system, comprising:

• a percutaneous fluid delivery cannula comprising a lumen extending from a proximal-most opening to a distal portion, the distal portion comprising a port in fluid communication with the lumen;
• and
• a reservoir defining an internal chamber containing a mixture of denaturing reagents, wherein a fluid output of the internal chamber of the reservoir is connected to the proximal-most opening of the lumen and in fluid communication with the lumen of the percutaneous fluid delivery cannula such that the denaturing reagents are contemporaneously deliverable through the proximal-most opening of the lumen and out of the port so as to denature components of cells present at the targeted site to locally ablate bodily tissue proximate the distal portion of the percutaneous fluid delivery cannula.