US 8,730,047 B2 · System for noninvasive determination of analytes in tissue

Abstract

An apparatus and method for noninvasive determination of analyte properties of human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems can include an illumination/modulation subsystem, a tissue sampling subsystem, a data acquisition subsystem, a computing subsystem, and a calibration subsystem. The invention can provide analyte property determination and identity determination or verification from the same spectroscopic information, making unauthorized use or misleading results less likely than in systems that use separate analyte and identity determinations. The invention can be used to control and monitor individuals accessing controlled environments.

Claims19

Dependent claims

An apparatus for determining the presence of one or more analytes in the tissue of one or more individuals, comprising one or more spectroscopic instruments, wherein each spectroscopic instrument comprises:

(a) a spectroscopic system configured to determine a spectroscopic signal from the response of at least a portion of the individual's tissue to incident electromagnetic radiation;
(b) an analysis system configured to determine from the spectroscopic signal one or more analyte properties characteristic of the individual;
wherein the analysis system is further configured to determine an identity characteristic of the individual from the spectroscopic signal;
and
(c) an the action initiation system configured to initiate an action responsive to both the identity characteristic and the one or more analyte properties.

2 more elements

An apparatus for monitoring access to a controlled environment responsive to the presence of one or more analytes in the tissue of one or more individuals, comprising

(a) one or more spectroscopic instruments, wherein each spectroscopic instrument comprises:
(a1) a spectroscopic system configured to determine a spectroscopic signal from the response of at least a portion of the individual's tissue to incident electromagnetic radiation;
and
(a2) an analysis system configured to determine from the spectroscopic signal one or more analyte properties characteristic of the individual;
and
(b) an action initiation system configured to perform at least one of the following:
communicate the one or more analyte properties to an agent associated with the controlled environment;
record the one or more analyte properties;
allow or disallow access to the controlled environment based on the one or more analyte properties;
or communicate to an agent associated with the controlled environment the result of a comparison of the one or more analyte properties with predetermined values.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/444,989Filed 12 Apr 2012 · continuation in part

Priority

24 May 2004

Published

US 2012/0197096 A12 Aug 2012

Granted

20 May 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification21 codes

A61B 5/0075
Using light, e.g. diagnosis by transillumination, diascopy, fluorescence: by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy,…
A61B 5/14546
Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g.…: for…
A61B 5/1455
Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g.…: using…
A61B 5/1495
Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g.…:…

Family

Application10/852,415Parent of this continuation-in-part · filed 24 May 2004

Application11/305,964Parent of this continuation-in-part · filed 19 Dec 2005

Application11/515,565Parent of this continuation-in-part · filed 5 Sep 2006

Application61/147,107Us provisional application · filed 25 Jan 2009

Application12/562,050Parent of this continuation-in-part · filed 17 Sep 2009

US 2012/0197096 A1Pre-grant publication · published 2 Aug 2012

US 8,174,394 B2Parent of this continuation-in-part

US 7,616,123 B2Parent of this continuation-in-part

US 7,756,558 B2Parent of this continuation-in-part

US 7,403,804 B2Parent of this continuation-in-part

US 2005/0261560 A1Published application

US 2007/0073118 A1Published application

US 2007/0142720 A1Published application

US 2008/0171924 A9Published application

US 2010/0010325 A1Published application

US 8,730,047 B2This patent

From the US filing history. Foreign family members aren’t listed.

System for noninvasive determination of analytes in tissue

Life of this patent

System for noninvasive determination of analytes in tissue

Life of this patent

Abstract

Claims19