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US 8,729,293 B2Granted
Fatty acid acetylated salicylates and their uses
AssigneeCatabasis Pharmaceuticals, Inc.
InventorsJill C. Milne, Michael R. Jirousek, Jean E. Bemis, Jesse J. Smith
Life of this patent
Estimating the term…
Abstract
The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.
Claims8
A compound of Formula III,
- or a pharmaceutically acceptable salt, enantiomer, or stereoisomer thereof,
- wherein
- W1 is null and W2 is independently selected from null, O, or NH;
- ----- represents an optional bond that when present requires that Q is null;
- each a and c are independently H, CH3, —OCH3, —OCH2CH3, or C(O)OH;
- each b is H, CH3, C(O)OH, or O—Z;
- each d is H or C(O)OH;
- each n, o, p, and q is independently 0 or 1;
- each Z is H or
- with the proviso that there is at least one
- in the compound;
- each r is independently 2, 3, or 7;
- each s is independently 3, 5, or 6;
- each t is 1;
- u is 0 or 1;
- with the proviso that when r is 7, s is 3;
- Q is null, C(O)CH3, Z,
- e is H or any one of the side chains of the naturally occurring amino acids;
- W3 is null, —O—, or —N(R)—;
- R is H or C1-C3 alkyl;
- and
- T is H, C(O)CH3, or Z.
19 more elements
A compound of Formula IIIa,
- or a pharmaceutically acceptable salt, enantiomer, or stereoisomer thereof,
- wherein
- W1 is null and W2 is independently selected from null, O, or NH;
- ----- represents an optional bond that when present requires that Q is null;
- each a and c are independently H, CH3, —OCH3, —OCH2CH3, or C(O)OH;
- each b is H, CH3, C(O)OH, or O—Z;
- each d is H or C(O)OH;
- each n, o, p, and q is independently 0 or 1;
- each Z is H or
- with the proviso that there is at least one
- in the compound;
- each r is independently 2, 3, or 7;
- each s is independently 3, 5, or 6;
- each t is 1
- with the proviso that when r is 7, s is 3;
- each Q is null, H, C(O)CH3, Z,
- each e is H or any one of the side chains of the naturally occurring amino acids;
- W3 is null, —O—, or —N(R)—;
- R is H or C1-C3 alkyl;
- and
- T is H, C(O)CH3, or Z.
18 more elements
A pharmaceutical composition comprising a compound of Formula III,
- or a pharmaceutically acceptable salt, enantiomer, or stereoisomer thereof,
- wherein
- W1 is null and W2 is independently selected from null, O, or NH;
- ----- represents an optional bond that when present requires that Q is null;
- each a and c are independently H, CH3, —OCH3, —OCH2CH3, or C(O)OH;
- each b is H, CH3, C(O)OH, or O—Z;
- each d is H or C(O)OH;
- each n, o, p, and q is independently 0 or 1;
- each Z is H or
- with the proviso that there is at least one
- in the compound;
- each r is independently 2, 3, or 7;
- each s is independently 3, 5, or 6;
- each t is 1;
- u is 0 or 1;
- with the proviso that when r is 7, s is 3;
- Q is null, C(O)CH3, Z,
- e is H or any one of the side chains of the naturally occurring amino acids;
- W3 is null, —O—, or —N(R)—;
- R is H or C1-C3 alkyl;
- and
- T is H, C(O)CH3, or Z;
- and a pharmaceutically acceptable carrier.
20 more elements
A pharmaceutical composition comprising a compound of Formula IIIa,
- or a pharmaceutically acceptable salt, enantiomer, and or stereoisomer thereof,
- wherein
- W1 is null and W2 is independently selected from null, O, or NH;
- ----- represents an optional bond that when present requires that Q is null;
- each a and c are independently H, CH3, —OCH3, —OCH2CH3, or C(O)OH;
- each b is H, CH3, C(O)OH, or O—Z;
- each d is H or C(O)OH;
- each n, o, p, and q is independently 0 or 1;
- each Z is H or
- with the proviso that there is at least one
- in the compound;
- each r is independently 2, 3, or 7;
- each s is independently 3, 5, or 6;
- each t is 1;
- with the proviso that when r is 7, s is 3;
- each Q is null, H, C(O)CH3, Z,
- each e is H or any one of the side chains of the naturally occurring amino acids;
- W3 is null, —O—, or —N(R)—;
- R is H or C1-C3 alkyl;
- and
- T is H, C(O)CH3, or Z;
- and a pharmaceutically acceptable carrier.
19 more elements
Dependencies are inferred from the claim text.