Neural tourniquet
AssigneeThe Feinstein Institute for Medical Research
InventorsKevin J. Tracey, Carol Ann Amella, Christopher Czura
Life of this patent
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Abstract
Disclosed is a method of reducing bleed time in a subject by activation of the cholinergic anti-inflammatory pathway in said subject. The cholinergic anti-inflammatory pathway can be activated by direct or indirect stimulation of the vagus nerve. The cholinergic anti-inflammatory pathway can also be activated by administering an effective amount of cholinergic agonist or acetylcholinesterase inhibitor to the subject.
Claims24
A method of reducing bleed time in a subject suffering bleeding, the method comprising activating the cholinergic anti-inflammatory pathway by stimulating the vagus nerve with a signal current of less than 10 mA;
- and reducing bleed time of the bleeding by at least 20%.
A method of reducing bleed time in a subject expected to suffer bleeding during a surgical procedure, the method comprising activating the cholinergic anti-inflammatory pathway by stimulating the vagus nerve with a signal current of less than 10 mA, wherein the cholinergic anti-inflammatory pathway is stimulated prior to the surgical procedure;
- performing the surgical procedure;
- and reducing bleeding that resulted from the surgical procedure by at least 20%.
A method of reducing bleed time in a subject suffering bleeding, the method comprising activating the cholinergic anti-inflammatory pathway by stimulating the vagus nerve with a constant voltage of between about 0.01V to 10V;
- and reducing bleed time of the bleeding by at least 20%.
A method of reducing bleed time in a subject suffering bleeding, the method comprising activating the cholinergic anti-inflammatory pathway by stimulating the vagus nerve without decreasing the heart rate of the subject;
- and reducing bleed time of the bleeding by at least 20%.
A method of reducing bleed time in a subject in need of such treatment, the method comprising activating the cholinergic anti-inflammatory pathway by stimulating the vagus nerve;
- and reducing bleed time of the bleeding by at least 20%, wherein the subject is suffering bleeding caused by a wound.
Dependencies are inferred from the claim text.