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US 8,722,370 B2Granted
Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family, having attenuated expression of gene(s) encoding peptidase
AssigneeAjinomoto Co., Inc.
InventorsDmitriy Vladimirovich Filippov, Tatyana Viktorovna Leonova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner, Mika Moriya, Yuri Nagai, Keiko Noguchi
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Abstract
The present invention provides a method for producing L-amino acids, such as L-arginine, L-citrulline, and L-lysine, using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of one or more genes, such as the pepA, pepB, and pepD genes.
Claims6
A method for producing an L-amino acid comprising:
- cultivating a bacterium of the Enterobacteriaceae family having an ability to produce an L-amino acid in a culture medium;
- and
- collecting the L-amino acid from the culture medium;
- wherein said bacterium has been modified to attenuate expression of a gene selected from the group consisting of pepA, pepB, pepD, and combinations thereof;
- and
- wherein the L-amino acid is selected from the group consisting of L-arginine, L-citruline, and L-lysine.
3 more elements
Dependencies are inferred from the claim text.