Compositions and methods for the treatment or prevention of hepatitis B virus infection
AssigneeGlobeImmune, Inc.
InventorsDavid Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott
Life of this patent
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Abstract
Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
Claims28
An immunotherapeutic composition comprising:
- a) a yeast vehicle;
- and
- b) a fusion protein comprising HBV antigens, wherein the HBV antigens consist of:
- i) an HBV X antigen having an amino acid sequence that is at least 95% identical to positions 1-60 of SEQ ID NO:130;
- ii) an HBV surface antigen having an amino acid sequence that is at least 95% identical to positions 63-461 of SEQ ID NO:130;
- and
- iii) an HBV core antigen having an amino acid sequence that is at least 95% identical to positions 462 to 643 of SEQ ID NO:130;
- wherein the composition elicits an HBV-specific immune response and wherein the fusion protein is expressed by the yeast vehicle.
An immunotherapeutic composition comprising:
- a) a whole, heat-inactivated yeast from Saccharomyces cerevisiae;
- and
- b) an HBV fusion protein expressed by the yeast, wherein the fusion protein comprises SEQ ID NO:130.
An immunotherapeutic composition comprising:
- a) a whole, heat-inactivated yeast from Saccharomyces cerevisiae;
- and
- b) an HBV fusion protein expressed by the yeast, wherein the fusion protein comprises SEQ ID NO:150.
A yeast expressing a fusion protein comprising HBV antigens, wherein the HBV antigens consist of:
- a) an HBV X antigen having an amino acid sequence that is at least 95% identical to positions 1-60 of SEQ ID NO:130;
- b) an HBV surface antigen having an amino acid sequence that is at least 95% identical to positions 63-461 of SEQ ID NO:130;
- and
- c) an HBV core antigen having an amino acid sequence that is at least 95% identical to positions 462 to 643 of SEQ ID NO:130.
A fusion protein comprising HBV antigens, wherein the fusion protein comprises an amino acid sequence that is at least 95% identical to an amino acid sequence of SEQ ID NO:130 or SEQ ID NO:150.
A fusion protein comprising HBV antigens, wherein the fusion protein comprises an amino acid sequence of SEQ ID NO:130 or SEQ ID NO:150.
Dependencies are inferred from the claim text.