Methods for treating malignancies using coxsackieviruses
AssigneeViralytics Limited
InventorDarren R. Shafren
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Abstract
There is a disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF.
Claims10
A method of treating abnormal cells in a mammal, comprising administering to the mammal an effective amount of a human Enterovirus-C (HEV-C) that binds to intercellular adhesion molecule-1 (ICAM-1) for infectivity of the abnormal cells and is thereby capable of infecting the abnormal cells whereby death of the cells is caused, wherein the abnormal cells are cancer cells, and further wherein the HEV-C is administered intravenously, intratumorally, intraperitoneally or intramuscularly.
Dependencies are inferred from the claim text.