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US 8,721,991 B2Granted
Microfluidic device for controlled aggregation of spider silk
AssigneeAmsilk GmbH
InventorsThomas Scheibel, Daniel Huemmerich, Sebastian Remmensee, Christian Freudiger, Andreas Bausch
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Abstract
The present invention is directed to a device and method of controlling the phase separation of one or a mixture of two or more spider silk proteins, leading to the defined and controllable assembly of the said silk protein(s) to defined morphologies, such as spheres, nano fibrils, threads, etc.
Claims6
A microfluidic device comprising:
- a) at least three microfluidic channels formed in said device comprising fluids flowing therethrough, wherein the channels converge in said microfluidic device to one combined channel in order to provide a laminar flow of said fluids, said combined channel leading to an outlet port;
- b) at least three inlet ports formed in said device to permit access to the at least three microfluidic channels;
- and
- c) at least three fluid storage means, each being connected via said inlet ports to one of the at least three microfluidic channels, characterized in that at least one of said storage means comprises a solution of one or more spider silk proteins and at least one of said storage means comprises an ionic solution comprising potassium and phosphate ions.
1 more element
Dependencies are inferred from the claim text.