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US 8,716,479 B2Granted
Methods for stereoselective reduction
AssigneeInfinity Pharmaceuticals, Inc.
InventorsBrian C. Austad, Andre Lescarbeau, Lin-Chen Yu
Life of this patent
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Abstract
The invention is directed to a method to reduce a C—C double bond of an enone of a steroidal compound to produce a mixture of β ketone product and α ketone product, comprising treating a solution or suspension of the steroidal compound in a solvent with hydrogen gas in the presence of a catalyst and a substituted pyridine.
Claims16
A method of making a mixture of a compound having formula V and a compound having formula VI:
- the method comprising treating a compound having formula VII:
- in a solvent with hydrogen gas in the presence of a palladium on carbon catalyst and a substituted pyridine, wherein the ratio of the β ketone product V to the α ketone product VI is at least 3:1.
A mixture comprising a compound of formula V, or a pharmaceutically acceptable salt thereof:
- and a compound of formula 2c, or a pharmaceutically acceptable salt thereof:
Dependencies are inferred from the claim text.