Dual variable domain immunoglobulins and uses thereof

A binding protein comprising first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C-(X2)n, wherein

• VD1 is a first variable domain;
• VD2 is a second variable domain;
• C is a constant domain;
• X1 is a linker;
• X2 is an Fc region;
• and
• n is 0 or 1;
• wherein the VD1 domains on the first and second polypeptide chains form a first functional target binding site and the VD2 domains on the first and second polypeptide chains form a second functional target binding site, and wherein the binding protein is capable of binding NGF and PGE2, wherein
• (1) the variable domains that form a functional target binding site for NGF comprise SEQ ID NO:
• 38 and/or SEQ ID NO:
• 39;
• and
• (2) the variable domains that form a functional target binding site for PGE2 comprise SEQ ID NO:
• 32 and/or SEQ ID NO:
• 33.

A binding protein capable of binding NGF and PGE2, wherein the binding protein comprises:

• DVD933 (comprising SEQ ID NOs:
• 48 and 49),
• DVD934 (comprising SEQ ID NOs:
• 50 and 51),
• DVD935 (comprising SEQ ID NOs:
• 52 and 53),
• DVD936 (comprising SEQ ID NOs:
• 54 and 55),
• DVD937 (comprising SEQ ID NOs:
• 56 and 57),
• DVD938 (comprising SEQ ID NOs:
• 58 and 59),
• DVD939 (comprising SEQ ID NOs:
• 60 and 61), or
• DVD940 (comprising SEQ ID NOs:
• 62 and 63).