Thiophenyl and pyrrolyl azepines as serotonin 5-HT2C receptor ligands and uses thereof
AssigneeAthersys, Inc.
InventorsL. Nathan Tumey, David C. Bom, Youssef L. Bennani, Michael J. Robarge
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Abstract
The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are thiophenyl and pyrrolyl azepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).
Claims3
A compound selected from the group consisting of:
- 3-Bromo-2-(2,2,2-trifluoro-ethyl)-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine;
- (R,S)-2-(2,2,2-Trifluoro-1-methyl-ethyl)-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine;
- 2-(2,2,2-Trifluoro-1,1-dimethyl-ethyl)-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine;
- 3-Bromo-4-methyl-2-(2,2,2-trifluoro-ethyl)-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine;
- (R,S)-2-(2,2,2-Trifluoro-ethyl)-4,4a,5,6,7,8-hexahydro-3H-1-thia-6-aza-cyclopenta[cd]azulene;
- and
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.