US 8,716,263 B2 · Synthesis of purine nucleosides

Abstract

A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.

Claims24

Dependent claims

A compound or salt thereof having the structure:

wherein R7 is C1-6 alkyl or C3-6 cycloalkyl and R8 is —O(C1-6 alkyl) or —O(C3-6 cycloalkyl).

Dependencies are inferred from the claim text.

Facts

Application

12/645,821Filed 23 Dec 2009 · us provisional application

Priority

23 Dec 2008

Published

US 2010/0279973 A14 Nov 2010

Granted

6 May 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

C07H 19/20
Purine radicals: with the saccharide radical esterified by phosphoric or polyphosphoric acids
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 31/12
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antivirals
A61P 31/14
Antivirals: for RNA viruses

Abstract

Claims24

Dependent claims

A compound or salt thereof having the structure:

wherein R7 is C1-6 alkyl or C3-6 cycloalkyl and R8 is —O(C1-6 alkyl) or —O(C3-6 cycloalkyl).

Dependencies are inferred from the claim text.

Synthesis of purine nucleosides

Life of this patent

Abstract

Claims24

Synthesis of purine nucleosides

Life of this patent

Abstract

Claims24