Inactivating pathogens with oxidizing agents for vaccine production
AssigneeOregon Health & Science University
InventorsMark K. Slifka, Shirley Villadiego, Erika Hammarlund, Paul Yoshihara
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Abstract
The present disclosure provides methods for producing a vaccine composition containing a pathogen that is rendered noninfectious by exposure to hydrogen peroxide. The methods disclosed herein are suitable for the preparation of vaccines for a wide variety of pathogens, including viruses, bacteria and parasites. The disclosure also provides vaccine compositions (medicaments) containing a pathogen inactivated by exposure to hydrogen peroxide. Methods for eliciting an immune response in a subject by administering vaccine compositions containing a hydrogen peroxide inactivated pathogen are also provided.
Claims13
A method for producing an immunogenic composition comprising an inactivated viral pathogen, the method comprising:
- contacting a viral pathogen with a solution comprising a chemical oxidizing agent in an amount and for a time-period sufficient for the chemical oxidizing agent to render the viral pathogen noninfectious while retaining viral immunogenicity;
- and verifying immunogenicity of the noninfectious virus by using it to elicit a virus-specific antibody, B cell or T cell response, or to reduce infection by the pathogen, or decrease symptoms that result from infection by the pathogen, wherein producing an immunogenic vaccine composition comprising an inactivated viral pathogen is afforded.
Dependencies are inferred from the claim text.