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US 8,715,689 B2Granted
Chimeric west nile/dengue viruses
AssigneeThe United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
InventorsClaire Y. H. Kinney, Eric Thomas Beck, Richard M. Kinney
Life of this patent
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Abstract
The disclosure provides chimeric West Nile/Dengue viruses comprising non-coding regions, non-structural proteins, and a C protein from a West Nile virus and prM and E proteins from a Dengue virus. Also disclosed are methods of using the chimeric viruses in diagnosis of Dengue viral infection, assessment of candidate Dengue virus vaccine efficacy, and production of Dengue prM and E proteins.
Claims22
A nucleic acid chimera comprising:
- a first nucleic acid molecule comprising a 5′ non-coding region, a nucleic acid encoding a C protein and non-structural proteins, and a 3′ non-coding region from a West Nile virus genome;
- and
- a second nucleic acid molecule operably linked to the first nucleic acid molecule, encoding at least a portion of a prM protein and E protein from a Dengue virus genome.
Dependencies are inferred from the claim text.