Human monoclonal antibody that specifically binds to VCAM-1 and a composition for treating an inflammatory disease or a cancer comprising the same

A human monoclonal antibody, or an antigen binding fragment thereof, that specifically binds to human vascular cell adhesion molecule-1 (VCAM-1) to inhibit the interaction between leukocytes and activated endothelial cells wherein the human monoclonal antibody comprises:

• (a) a heavy chain variable region that contains a heavy chain CDR1 as defined by SEQ ID NO. 2;
• a heavy chain CDR2 as defined by SEQ ID NO. 3;
• and a heavy chain CDR3 as defined by SEQ ID NO. 4, and a light chain variable region that contains a light chain CDR1 as defined by SEQ ID NO. 14;
• a light chain CDR2 as defined by SEQ ID NO. 15;
• and a light chain CDR3 as defined by SEQ ID NO. 16;
• (b) a heavy chain variable region that contains a heavy chain CDR1 as defined by SEQ ID NO. 6;
• a heavy chain CDR2 as defined by SEQ ID NO. 7;
• and a heavy chain CDR3 as defined by SEQ ID NO. 8, and a light chain variable region that contains a light chain CDR1 as defined by SEQ ID NO. 18;
• a light chain CDR2 as defined by SEQ ID NO. 19;
• and a light chain CDR3 as defined by SEQ ID NO. 20;
• (c) a heavy chain variable region that contains a heavy chain CDR1 as defined by SEQ ID NO. 10;
• a heavy chain CDR2 as defined by SEQ ID NO. 11;
• and a heavy chain CDR3 as defined by SEQ ID NO. 12, and a light chain variable region that contains a light chain CDR1 as defined by SEQ ID NO. 22;
• a light chain CDR2 as defined by SEQ ID NO. 23;
• and a light chain CDR3 as defined by SEQ ID NO. 24;
• or
• (d) an antigen binding fragment of (a), (b), or (c).