Method and apparatus for analysis of histopathology images and its application to cancer diagnosis and grading
AssigneeUniversity of Warwick
InventorsNasir Mahmood Rajpoot, Khalid Masood
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Abstract
The invention relates to histology analyses, and in particular, to the assessment of pathological tissues to aid in the diagnosis of disease characterized by specific pathologies, for example cancer. The invention provides methods and apparatuses for analyzing tissue samples, as well as computer-readable media programmed with software for carrying out these diagnostic methods.
Claims20
A computer-assisted diagnostic method to characterise and aid in diagnosing a disease in a subject, wherein the method comprises the steps of:
- (i) obtaining, from a subject, a histological image corresponding to a tissue sample comprising at least one node;
- (ii) identifying, in the image, the location of the at least one node;
- (iii) conducting random polygon modelling on the identified node to generate an output image which demarks the boundary of a closed shape structure satisfying certain criteria in the histological image;
- (iv) extracting at least one objective measurement from the output image;
- and
- (v) diagnosing the disease based on the at least one objective measurement.
A non-transitory computer-readable medium comprising computer executable instructions to be run by a processor to process histological image data corresponding to a tissue sample comprising at least one node so as to:
- (i) identify in the image data, node location data corresponding the location of the at least one node;
- (ii) conduct random polygon modelling on the identified node data to generate output image data corresponding to the boundary of at least one closed shape structure whereby to permit characteristics of the closed shape structure to be determined for use in diagnosing the disease.
An apparatus for characterising and aiding in diagnosing a disease in a subject, comprising a processor with an input to receive histological image data corresponding to a tissue sample comprising at least one node, the processor being configured to:
- (i) identify, in the image data, node location data corresponding to the location of the at least node;
- and
- (ii) conduct random polygon modelling on the identified node data to generate output image data corresponding to the boundary of a closed shape structure, whereby to permit characteristics of the closed shape structure to be determined for use in characterising and aiding in diagnosing the disease.
Dependencies are inferred from the claim text.